General
Preferred name
NEBOGLAMINE
Synonyms
CR 2249 ()
XY 2401 hydrochloride ()
CR-2249 hydrochloride ()
Neboglamine (hydrochloride) ()
CR-2249 (hydrochloride) ()
XY-2401 (hydrochloride) ()
Neboglamine hydrochloride ()
XY-2401 ()
Nebostinel ()
Cr2249 ()
Neboglamina ()
P&D ID
PD002669
CAS
163000-63-3
2759182-59-5
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Neboglamine (CR-2249, XY-2401) hydrochloride is an orally active NMDA receptor glycine site positive modulator that can be used in schizophrenia research[1].
PRICE 598
DESCRIPTION Facilitates glycine action at NMDA glutamate receptors (LOPAC library)
DESCRIPTION Neboglamine (CR-2249, XY-2401) hydrochloride, an orally active positive modulator of the NMDA receptor glycine site, can be used in schizophrenia research [1]. (TargetMol Bioactive Compound Library)
Compound Sets
7
ChEMBL Drugs
CHEMBL1255840
LOPAC library
MedChem Express Bioactive Compound Library
HY-114753A
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T60612
External IDs
19
Properties
(calculated by RDKit )
Molecular Weight
256.18
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
0
cLogP
1.26
TPSA
92.42
Fraction CSP3
0.85
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
iGluR
NMDA
Selectivity
NMDA-Glycine
Member status
member
MOA
NMDA Glycine-Site Modulators
Norepinephrine Reuptake Inhibitors
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data