General
Preferred name
PANCURONIUM BROMIDE
Synonyms
Pavulon ()
Pancuronium (dibromide) ()
Pancuronium dibromide ()
Bromurex ()
Mioblock ()
Bromure de pancuronium ()
Bromuro de pancuronio ()
ORG-NA 97 ()
NSC-293162 ()
ORG-NA-97 ()
ORG NA 97 ()
P&D ID
PD002658
CAS
15500-66-0
Tags
available
drug
Drug Status
approved
Max Phase
4.0
First approval
1972
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action[1][2][3].
PRICE 57
DESCRIPTION Aminosteroidal neuromuscular blocking agent; skeletal muscle relaxant (LOPAC library)
DESCRIPTION Pancuronium results in open channel block of embryonic-type nicotinic acetylcholine receptor channels after coapplication of blocker and acetylcholine. (BOC Sciences Bioactive Compounds)
DESCRIPTION Pancuronium dibromide (Pavulon), a competitive AChR antagonist (IC50 = 5.5 nM), acts as a skeletal muscle relaxant. Pancuronium dibromide(Pancuronium bromide) blocking neuromuscular transmission is achieved by competing with acetylcholine for receptor sites on the motor end-plate. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
BOC Sciences Bioactive Compounds
pancuronium-dibromide-cas-15500-66-0-item-84-59734
ChEMBL Approved Drugs
CHEMBL1200757
ChEMBL Drugs
CHEMBL1200757
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0429
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Pancuronium-bromide(Pavulon)
TargetMol Bioactive Compound Library
T0166
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
730.29
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
6
Aromatic Ring Count
0
cLogP
0.12
TPSA
52.6
Fraction CSP3
0.94
Chiral centers
10.0
Largest ring
6.0
QED
0.31
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
AChR
mAChR
nAChR
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Source data