General
Preferred name
ENPROFYLLINE
Synonyms
3-n-Propylxanthine ()
3-Propylxanthine (enprofylline) ()
Enprofilina ()
3-propylxanthine ()
Enprofyllinum ()
PMID28870136-Compound-47 ()
3-Propylxanthine ()
D-4028 ()
D 4028 ()
P&D ID
PD002654
CAS
41078-02-8
Tags
available
drug
Drug indication
Asthma
Drug Status
approved
experimental
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Enprofylline acts as a selective and competitive A2B receptor antagonist with the Ki of 7 ¦ÌM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease[1][2][3].
PRICE 50
DESCRIPTION Weak competitive antagonist at both A1 and A2 adenosine receptors (LOPAC library)
DESCRIPTION Enprofylline is a derivative of theophylline which shares bronchodilator properties. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. (Enamine Bioactive Compounds)
DESCRIPTION Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sickle cell disease, diabetic neuropathy, and cerebrovascular insufficiency. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
18
Cayman Chemical Bioactives
21746
ChEMBL Drugs
CHEMBL279898
Drug Repurposing Hub
DrugBank
DB00824
DrugBank Approved Drugs
DB00824
DrugCentral
1015
DrugCentral Approved Drugs
1015
DrugMAP
DMFYZKN
DMYWBRX
DrugMAP Approved Drugs
DMFYZKN
DrugMatrix
Enamine Bioactive Compounds
EBC-06370
Enamine BioReference Compounds
Ki Database
3-Propylxanthine (enprofylline)
Enprofylline
LOPAC library
MedChem Express Bioactive Compound Library
HY-14117
NPC Screening Collection
ReFrame library
TargetMol Bioactive Compound Library
T21389
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
194.08
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.18
TPSA
83.54
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
A1 > A2
Target
ADORA1, ADORA2A, ADORA2B, ADORA3, PDE4A, PDE4B
Adenosine Receptor
Phosphodiesterase (PDE)
MOA
phosphodiesterase inhibitor
Therapeutic Class
Antiinflammatory Agents
Pathway
GPCR/G protein
Metabolic Enzyme/Protease
Source data