General
Preferred name
PICEATANNOL
Synonyms
ML027 ()
Astringenin ()
trans-Piceatannol ()
4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-1,2-benzenediol ()
P&D ID
PD002653
CAS
10083-24-6
4339-71-3
Tags
available
probe
drug candidate
nuisance
obsolete probe
Drug indication
Discovery agent
Drug Status
experimental
Probe info
Probe type
experimental probe
Probe sources
MLP Probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Piceatannol is a well-known Syk inhibitor and reduces the expression of iNOS induced by TNF. Piceatannol is an effective agent for research of acute lung injury (ALI)[1]. Piceatannol is a naturally occurring polyphenolic stilbene found in various fruits and vegetables and exhibits anticancer and anti-inflammatory properties[2]. Piceatannol induces apoptosis in DLBCL cell lines[3]. Piceatannol induces autophagy and apoptosis in MOLT-4 human leukemia cells[4].
PRICE 32
DESCRIPTION Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-??B activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1.
DESCRIPTION To identify selective exosite/active site inhibitors of A Disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) (MLP Probes)
DESCRIPTION Non-receptor kinase Syk and Lck inhibitor (LOPAC library)
DESCRIPTION Inhibits TNF-induced NF-κB activation (Tocriscreen Total)
DESCRIPTION Inhibitor of Hedgehog (Hh) signaling. Inhibits delta7-dehydrocholesterol reductase (Tocris Bioactive Compound Library)
DESCRIPTION Piceatannol (Astringenin) is an anti-inflammatory, immunomodulatory and antiproliferative agent. It inhibits p56lck and syk protein tyrosine kinases and inhibits NF-κB activation and gene expression of TNF-induced. It is synthetic from the conversion of resveratrol by cytochrome P450 1B1. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
6
Compound Sets
17
AdooQ Bioactive Compound Library
A12162
Cayman Chemical Bioactives
10009366
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB08399
DrugMAP
DMYOP45
LOPAC library
MedChem Express Bioactive Compound Library
HY-13518
MLP Probes
MLSMR Probes +
Nuisance compounds in cellular assays
Obsolete Compounds
piceatannol
ReFrame library
Selleckchem Bioactive Compound Library
piceatannol
TargetMol Bioactive Compound Library
T0610
Tocris Bioactive Compound Library
1554
Tocriscreen Total
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
244.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
2.68
TPSA
80.92
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.48
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Nonspecific/NOS
Resveratrols
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Classification
Probe
Selectivity
Syk / Lck
Primary Target
NF-?B and I?B
MOA
Inhibitor
Syk inhibitor
Target
ATP5A1, ATP5B, ATP5C1, IRF3
Endogenous Metabolite
SYK
Arginase,Syk
cAK
MLCK
PKC
Pathway
Angiogenesis
Apoptosis
Autophagy
Cell Cycle/Checkpoint
Chromatin/Epigenetic
Cytoskeletal Signaling
Metabolism
Tyrosine Kinase/Adaptors
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Source data