General
Preferred name
TPCA-1
Synonyms
TPCA 1 ()
GW683965 ()
IKK2 Inhibitor IV ()
TPCA1 ()
GW789449X ()
2-(carbamoylamino)-5-(2-fluorophenyl)thiophene-3-carboxamide ()
IKK-2 inhibitor IV ()
P&D ID
PD002651
CAS
507475-17-4
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This compound is an inhibitor of IKKβ (IKK2) . (GtoPdb)
DESCRIPTION inhibitor of IKK-2 (Informer Set)
DESCRIPTION Potent, selective inhibitor of IKKbeta (Tocriscreen Plus)
DESCRIPTION Potent and selective inhibitor of human IkB kinase-2 (IKK-2) used to study inflammation in animal models. (LOPAC library)
DESCRIPTION Chk1 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Potent, selective inhibitor of IKK-2 (Tocriscreen Total)
Compound Sets
22
AdooQ Bioactive Compound Library
A11579
Cayman Chemical Bioactives
15115
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB17058
DrugMAP
DMA14PR
EU-OPENSCREEN Bioactive Compound Library
EOS101051
Guide to Pharmacology
5986
Informer Set
375564
LINCS compound set
10136-101
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-8354707197
MedChem Express Bioactive Compound Library
HY-10074
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
tpca-1
TargetMol Bioactive Compound Library
T3049
Tocris Bioactive Compound Library
2559
Tocriscreen Plus
2559
Tocriscreen Total
Welcome Trust Cancer Drugs
305
ZINC Tool Compounds
ZINC000003960707
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
279.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.14
TPSA
98.21
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
IKBKB
IKK
IKK2
STAT
Apoptosis related,I??/IKK,NF-??,STAT
Compound status
probe
Target Type
Enzymes
Selectivity
IKK-2
Pathway
NF-¦ÊB
NF-??b
NF-??
Apoptosis
JAK/STAT Signaling
NF-κB
Stem Cell/Wnt
Primary Target
I?B Kinase
MOA
Inhibitor
IKK-2 (IKK-beta) Inhibitors
IKK inhibitor
Member status
member
Source data