General
Preferred name
TPCA-1
Synonyms
GW683965 ()
IKK2 Inhibitor IV ()
TPCA1 ()
GW789449X ()
2-(carbamoylamino)-5-(2-fluorophenyl)thiophene-3-carboxamide ()
IKK-2 inhibitor IV ()
P&D ID
PD002651
CAS
507475-17-4
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This compound is an inhibitor of IKKβ (IKK2) .
(GtoPdb)
DESCRIPTION
TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.
PRICE
65
DESCRIPTION
inhibitor of IKK-2
(Informer Set)
DESCRIPTION
Chk1 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent, selective inhibitor of IKKbeta
(Tocriscreen Plus)
DESCRIPTION
Potent and selective inhibitor of human IkB kinase-2 (IKK-2) used to study inflammation in animal models.
(LOPAC library)
DESCRIPTION
Potent, selective inhibitor of IKK-2
(Tocriscreen Total)
DESCRIPTION
TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
22
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
Informer Set
LINCS compound set
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Welcome Trust Cancer Drugs
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
279.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
2.14
TPSA
98.21
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
IKBKB
IKK
Apoptosis
IKK2
STAT
Apoptosis related,I¦ÊB/IKK,NF-¦ÊB,STAT
Compound status
probe
Target Type
Enzymes
Selectivity
IKK-2
Pathway
NF-¦ÊB
NF-??
JAK/STAT Signaling
NF-κB
Stem Cells
Stem Cell/Wnt
Primary Target
I?B Kinase
MOA
Inhibitor
IKK-2 (IKK-beta) Inhibitors
IKK inhibitor
Member status
member
Source data
