General
Preferred name
TYRPHOSTIN A9
Synonyms
AG 17 ()
SF 6847 ()
RG-50872 ()
Malonoben ()
Tyrphostin 9 ()
AG-17 ()
SF 6847, RG-50872 ()
P&D ID
PD002632
CAS
10537-47-0
Tags
natural product
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective PDGF tyrosine kinase receptor inhibitor
(LOPAC library)
DESCRIPTION
Tyrphostin 9 is firstly designed as an EGFR inhibitor with IC50 of 460 μM, but is also found to be more potent to PDGFR with IC50 of 0.5 μM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
3
Compound Sets
10
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
282.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
4.42
TPSA
67.81
Fraction CSP3
0.44
Chiral centers
0.0
Largest ring
6.0
QED
0.78
QED
0.78
Structural alerts
1
ene_cyano_A(19)
[#6](-[#6]#[#7])(-[#6]#[#7])=[#6]-c:1:c:c:c:c:c:1
PAINS Family B
Related compounds
Custom attributes
(extracted from source data)
Selectivity
PDGFR
Pathway
Angiogenesis
JAK/STAT Signaling
Tyrosine Kinase/Adaptors
Chromatin/Epigenetic
Anti-infection
Protein Tyrosine Kinase/RTK
Target
EGFR
Influenza Virus
VEGFR
EGFR,PDGFR
MOA
protein tyrosine kinase inhibitor, tyrosine kinase inhibitor
Solubility
In Vitro:<br/>DMSO : ≥ 100 mg/mL (354.13 mM)<br/>H2O : < 0.1 mg/mL (insoluble)
Source data
