General
Preferred name
trans-Urocanic Acid
Synonyms
4-Imidazoleacrylic acid ()
trans-UCA ()
(E)-Urocanic acid ()
Urocanic-acid Hydrochloride ()
cis-urocanic acid, emulsion, BioCis ()
Urocanic acid ()
P&D ID
PD002631
CAS
7699-35-6
6159-48-4
104-98-3
3465-72-3
Tags
available
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Urocanic acid, produced in the upper layers of mammalian skin, is a major absorber of ultraviolet radiation (UVR).
DESCRIPTION
trans-urocanic acid (trans-UCA), a natural epidermal constituent, inhibits human natural killer cell (NK) activity in vitro. trans-urocanic acid is active in regulating an immune function[1].
PRICE
29
DESCRIPTION
Histidine ammonia-lyase and decarboxylase inhibitor
(LOPAC library)
DESCRIPTION
Urocanic acid (4-Imidazoleacrylic acid), synthesized in the epidermis, functions as a primary absorber of ultraviolet (UV) radiation in mammalian skin.
(TargetMol Bioactive Compound Library)
DESCRIPTION
trans-Urocanic Acid ((E)-Urocanic acid), a compound predominantly distributed in the hippocampus and prefrontal cortex, is an isomer of cis-UCA, an epidermal UV-protectant, which enhances the stability of tenofovir eplerenomide in long-acting HIV applications. trans-Urocanic acid potently modulates immune trans-urocanic acid effectively modulates immune function, inhibits human natural killer cell activity in vitro, and can be used in Alzheimer's disease research.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
8
Cayman Chemical Bioactives
DrugBank
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Molecular Weight
138.04
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
0.51
TPSA
65.98
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
5.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Histidine ammonia-lyase/ decarboxylase
Target
Endogenous Metabolite
HTR2A
Phase
Phase 2
MOA
serotonin receptor agonist
Pathway
Metabolic Enzyme/Protease
Metabolism
Source data
