General
Preferred name
PHENTOLAMINE MESYLATE
Synonyms
Phentolamine methanesulfonate ()
PHENTOLAMINE ()
Phentolamine mesilate ()
Phentolamine (mesylate) ()
Oraverse ()
Mesylate phentolamine ()
Rogitine ()
Regitine ()
NV-101 ()
P&D ID
PD002622
CAS
65-28-1
50-60-2
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Anti-Adrenergic
First approval
1952
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION ATP-sensitive K+ channel blocker; alpha adrenoceptor antagonist (LOPAC library)
DESCRIPTION Potent and selective CRF1 antagonist; anxiolytic (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
12
AdooQ Bioactive Compound Library
A11734
Axon Medchem Screening Library
3510
Cayman Chemical Bioactives
16135
ChEMBL Approved Drugs
CHEMBL1200873
ChEMBL Drugs
CHEMBL1200873
EU-OPENSCREEN Bioactive Compound Library
EOS100368
Ki Database
PHENTOLAMINE
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0362A
Selleckchem Bioactive Compound Library
phentolamine-mesilate
TargetMol Bioactive Compound Library
T1275
Tocris Bioactive Compound Library
6431
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
377.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
2.34
TPSA
102.23
Fraction CSP3
0.28
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??-adrenergic receptor
??-adrenoceptor
a1/a2 antagonist
Adrenergic Receptor
Primary Target
Non-selective Adrenergic ? Receptors
MOA
Antagonist
Source data