General
Preferred name
o-Phenanthroline
Synonyms
1,10-Phenanthroline monohydrate ()
1,10-Phenanthroline ()
1, 10-Phenanthroline monohydrate ()
PHENANTHROLINE ()
o-Phenanthroline (monohydrate) ()
1,10-Phenanthroline (monohydrate) ()
Phenanthroline monohydrate ()
1,10-Phenanthroline, phen ()
o-Phenanthroline monohydrate ()
1,10-Phenanthroline (hydrate) ()
P&D ID
PD002621
CAS
66-71-7
5144-89-8
Tags
available
drug candidate
nuisance
obsolete probe
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 1,10-Phenanthroline has an affinity for zinc ions, that facilitates its action as an inhibitor of zinc metallopeptidases, such as carboxypeptidase A . (GtoPdb)
PRICE 29
DESCRIPTION o-Phenanthroline (1,10-Phenanthroline) monohydrate, a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline monohydrate forms a red chelate with Fe2+ that absorbs maximally at 510 nm. o-Phenanthroline (1,10-Phenanthroline) monohydrate is also a MMP inhibitor[1][2].
PRICE 29
DESCRIPTION RAD51 recombinase inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Metalloprotease inhibitor; chelates iron, zinc and other divalent metals (LOPAC library)
DESCRIPTION o-Phenanthroline is a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. It is a matrix metalloproteinase (MMP) inhibitor. (Enamine Bioactive Compounds)
DESCRIPTION o-Phenanthroline (1,10-Phenanthroline) , a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells.o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation. (TargetMol Bioactive Compound Library)
DESCRIPTION 1,10-Phenanthroline is a classic chelating bidentate ligand for transition metal ions that has played an important role in the development of coordination chemistry. It is an inhibitor of metallopeptidases. (BOC Sciences Bioactive Compounds)
DESCRIPTION o-Phenanthroline monohydrate (1, 10-Phenanthroline monohydrate) is an inhibitor of metallopeptidases, inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
4
Compound Sets
13
BOC Sciences Bioactive Compounds
1-10-phenanthroline-monohydrate-cas-5144-89-8-item-295995
Cayman Chemical Bioactives
28951
Concise Guide to Pharmacology 2023/24
12425
DrugBank
DB02365
Enamine Bioactive Compounds
EBC-44315
Guide to Pharmacology
12425
LOPAC library
MedChem Express Bioactive Compound Library
HY-Y1841
Nuisance compounds in cellular assays
Obsolete Compounds
phenanthroline
Selleckchem Bioactive Compound Library
o-phenanthroline
1-10-phenanthroline-monohydrate
TargetMol Bioactive Compound Library
T5983
T7449
Tocris Bioactive Compound Library
6385
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
180.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
3
cLogP
2.78
TPSA
25.78
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.5
Structural alerts
2
historic compounds (Chemical Probes.org)
Obsolete
Chelation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Metalloprotease
Target
MMP
Primary Target
Neural Stem Cells
Pathway
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data