General
Preferred name
D-serine
Synonyms
(R)-Serine ()
(D)-SERINE ()
DEUTARSERINE ()
C-21692 ()
Ctp-692 ()
P&D ID
PD002617
CAS
312-84-5
62595-04-4
13095-79-9
Tags
drug candidate
natural product
drug
available
Drug Status
experimental
investigational
approved
Max Phase
Phase 2
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective GABAA agonist (Tocris Bioactive Compound Library)
DESCRIPTION Glycine mimic active at the strychnine-insensitive glycine binding site associated with the NMDA glutamate receptor as well as the inhibitory post-synaptic glycine receptor (LOPAC library)
Compound Sets
19
Cayman Chemical Bioactives
31197
ChEMBL Drugs
CHEMBL285123
CHEMBL4650463
Concise Guide to Pharmacology 2017/18
4171
Concise Guide to Pharmacology 2019/20
4171
Concise Guide to Pharmacology 2021/22
4171
Concise Guide to Pharmacology 2023/24
4171
Drug Repurposing Hub
DrugBank
DB03929
DrugBank Approved Drugs
DB03929
DrugMAP
DM3YH4I
Guide to Pharmacology
4171
LOPAC library
Mcule NIBR MoA Box Subset
MCULE-5604658333
MedChem Express Bioactive Compound Library
HY-100808
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
r-serine
TargetMol Bioactive Compound Library
T8394
Tocris Bioactive Compound Library
0226
External IDs
46
Properties
(calculated by RDKit )
Molecular Weight
105.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.61
TPSA
83.55
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
0.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA-Glycine
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Target
NMDA Receptor
GLRA1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SERPINB3
Endogenous Metabolite
iGluR
NMDAR
Primary Target
NMDA Receptors
MOA
Modulator
NMDA Glycine-Site Agonists
glutamate receptor agonist
Member status
virtual
Source data