General
Preferred name
D-serine
Synonyms
(R)-Serine ()
D-(-)-serine ()
(D)-SERINE ()
DEUTARSERINE ()
Ctp-692 ()
C-21692 ()
P&D ID
PD002617
CAS
312-84-5
62595-04-4
13095-79-9
Tags
available
drug
drug candidate
Drug Status
approved
investigational
experimental
Max Phase
3.0
2.0
Drug indication
Schizophrenia
cocaine dependence
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Selective GABAA agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Glycine mimic active at the strychnine-insensitive glycine binding site associated with the NMDA glutamate receptor as well as the inhibitory post-synaptic glycine receptor
(LOPAC library)
DESCRIPTION
D-Serine is a non-essential amino acid occurring in natural form as the L-isomer. D-Serine is subtype-specific agonists for NMDA receptor.
(Enamine Bioactive Compounds)
DESCRIPTION
D-Serine ((R)-Serine), an endogenous amino acid, is a potent co-agonist at the NMDA glutamate receptor.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Guide to Pharmacology
LOPAC library
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
105.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.61
TPSA
83.55
Fraction CSP3
0.67
Chiral centers
1.0
Largest ring
0.0
QED
0.39
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA-Glycine
Pathway
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Primary Target
NMDA Receptors
MOA
Modulator
NMDA Glycine-Site Agonists
glutamate receptor agonist
Member status
virtual
Target
GLRA1, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SERPINB3
NMDAR
Endogenous Metabolite
iGluR
NMDA Receptor
Source data
