General
Preferred name
LEVOSULPIRIDE
Synonyms
(S)-(-)-Sulpiride ()
(-)-sulpiride ()
S-(-)-Sulpiride ()
RV-12309 ()
RV-12309,S-(-)-Sulpiride ()
Levobren ()
Levopraid ()
Levopride ()
L-sulpiride ()
Sulpiride, (-)- ()
Lesuride ()
Sulpiride l-form ()
Sulpiride, (s)- ()
P&D ID
PD002616
CAS
23672-07-3
Tags
natural product
drug
available
Drug Status
experimental
investigational
approved
Max Phase
Phase 2
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The (-)-enantiomer of sulpiride is approved with the INN levosulpiride and is also a component of the approved drug . (GtoPdb)
DESCRIPTION D2 dopamine receptor antagonist; antipsychotic (LOPAC library)
DESCRIPTION Standard selective D2-like antagonist (Tocriscreen Plus)
DESCRIPTION Selective P2Y1 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Standard selective D2-like antagonist (Tocriscreen Total)
Compound Sets
21
ChEMBL Drugs
CHEMBL267044
Concise Guide to Pharmacology 2017/18
958
Concise Guide to Pharmacology 2019/20
958
Concise Guide to Pharmacology 2021/22
958
Concise Guide to Pharmacology 2023/24
958
Drug Repurposing Hub
DrugBank
DB16021
DrugCentral
1577
DrugCentral Approved Drugs
1577
EU-OPENSCREEN Bioactive Compound Library
EOS101654
Guide to Pharmacology
958
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL267044
MedChem Express Bioactive Compound Library
HY-B1059
NIH Clinical Collections (NCC)
ReFrame library
Selleckchem Bioactive Compound Library
levosulpiride-levogastrol
TargetMol Bioactive Compound Library
T1211
Tocris Bioactive Compound Library
0895
Tocriscreen Plus
0895
Tocriscreen Total
External IDs
29
Properties
(calculated by RDKit )
Molecular Weight
341.14
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
0.56
TPSA
101.73
Fraction CSP3
0.53
Chiral centers
1.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
D2
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
dopamine
CA1, CA12, CA7, DRD2, DRD3
Dopamine Receptor
Primary Target
Non-selective Dopamine
MOA
Antagonist
Dopamine Receptor antagonist
Indication
schizophrenia, psychosis, anxiety, vertigo, dyspepsia, irritable bowel syndrome, premature ejaculation (PE)
Disease Area
neurology/psychiatry, gastroenterology, urology
Source data