General
Preferred name
SALMETEROL XINAFOATE
Synonyms
Salmetedur ()
GR 33343X xinafoate ()
Arial ()
Salmeterol (xinafoate) ()
GR 33343X xinafoate,Salmetedur ()
SEREVENT ()
GR-33343X ()
Salmeterol xinafoate component of advair hfa ()
Salmeterol xinafoate component of lipo-102 ()
GR 33343 G ()
Salmeterol 1-hydroxy-2-naphthoate ()
GR-33343 G ()
LIPO-202 ()
Salmeterol xinafoate component of airduo respiclick ()
Salmeterol xinafoate component of advair ()
P&D ID
PD002614
CAS
94749-08-3
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Chronic obstructive pulmonary disease
First approval
1994
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Salmeterol (GR 33343X) xinafoate is a potent and selective human ¦Â2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human ¦Â2, ¦Â1 and ¦Â3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].
PRICE 81
DESCRIPTION Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting ??2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms.
DESCRIPTION beta2 Adrenoceptor agonist (LOPAC library)
DESCRIPTION Long-acting beta2 agonist; bronchodilator (Tocriscreen Plus)
DESCRIPTION Salmeterol Xinafoate (GR 33343X xinafoate) is a long-acting β2-adrenergic receptor agonist with anti-inflammatory effects, used in the treatment of asthma symptoms and chronic obstructive pulmonary disease (COPD) symptoms. (TargetMol Bioactive Compound Library)
DESCRIPTION Selective A2B antagonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
11
AdooQ Bioactive Compound Library
A14223
Cayman Chemical Bioactives
16009
ChEMBL Approved Drugs
CHEMBL1082607
ChEMBL Drugs
CHEMBL1082607
CZ-OPENSCREEN Bioactive Library
LOPAC library
MedChem Express Bioactive Compound Library
HY-17453
Selleckchem Bioactive Compound Library
salmeterol-xinafoate
TargetMol Bioactive Compound Library
T6653
Tocris Bioactive Compound Library
4712
Tocriscreen Plus
4712
External IDs
20
Properties
(calculated by RDKit )
Molecular Weight
603.32
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
6
Rotatable Bonds
17
Ring Count
4
Aromatic Ring Count
4
cLogP
6.35
TPSA
139.48
Fraction CSP3
0.36
Chiral centers
1.0
Largest ring
6.0
QED
0.08
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
beta2
Target
Adrenergic Receptor
WT β2AR
β2-adrenergic receptor
¦Â2-adrenergic receptor
Primary Target
Adrenergic ?2 Receptors
MOA
Adrenergic Receptor agonist
Agonist
Pathway
GPCR/G protein
Microbiology/virology
Neuroscience
Proteases/Proteasome
Neuronal Signaling
Source data