General
Preferred name
SEMAXANIB
Synonyms
SU5416 ()
SU 5416 ()
(Z)-Semaxinib ()
SU 5416 (Semaxinib) ()
Romiplostim ()
Semaxinib ()
NSC-696819 ()
SU-5416 ()
SU005416 ()
Semaxanib (SU5416) ()
P&D ID
PD002610
CAS
194413-58-6
204005-46-9
Tags
available
drug
Drug indication
Multiple myeloma
Thrombocytopenia
Myelodysplastic syndrome
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Semaxanib was a precursor in the development of the next generation kinase inhibitor ultimately approved as .
(GtoPdb)
DESCRIPTION
Investigated for use/treatment in colorectal cancer and lung cancer.
(PKIDB)
DESCRIPTION
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
(Tocriscreen Plus)
DESCRIPTION
Potent and selective VEGFR PTK inhibitor; inhibits VEGF-induced angiogenesis
(LOPAC library)
DESCRIPTION
ACAT inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
3
Compound Sets
24
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMAP Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
PKIDB
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
238.11
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.12
TPSA
44.89
Fraction CSP3
0.13
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
2
aggregator (ZINC)
Aggregators
aggregator (Aggregator Advisor)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzyme-Linked Receptors
Selectivity
VEGFR PTK
Pathway
Angiogenesis
Tyrosine Kinase/Adaptors
Protein Tyrosine Kinase/RTK
Target
VEGFR2/Flk1
FGFR1, FLT1, KDR, KIT, PDGFRA, PDGFRB, RET
KDR
Primary Target
VEGFR
MOA
Inhibitor
VEGFR inhibitor
Source data
