General
Preferred name
AG-1478
Synonyms
Tyrphostin AG 1478 ()
AG 1478 ()
NSC 693255 ()
TYRPHOSTIN AG-1478 ()
Tyrphostin ()
AG1478 ()
AG 1478 hydrochloride ()
AG-1478 (Tyrphostin AG-1478) ()
P&D ID
PD002607
CAS
153436-53-4
170449-18-0
175178-82-2
Tags
available
drug candidate
probe
Drug indication
Discovery agent
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
65
No orthogonal probes found
Similar probes
46
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tyrphostin AG 1478 is a selective inhibitor of the EGFR tyrosine kinase. It is compound 4 in .
(GtoPdb)
DESCRIPTION
Selective inhibitor of epidermal growth factor receptor (EGFR) protein
(LOPAC library)
DESCRIPTION
NTPDase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
The hydrochloride salt form of AG 1478, which has been found to be an epidermal growth factor receptor tyrosine kinase inhibitor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
2
Compound Sets
15
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugMAP
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LINCS compound set
LOPAC library
MedChem Express Bioactive Compound Library
Probe Miner (suitable probes)
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
315.08
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
4.04
TPSA
56.27
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
EGFR
Pathway
Angiogenesis
JAK/STAT Signaling
Tyrosine Kinase/Adaptors
Chromatin/Epigenetic
Anti-infection
Protein Tyrosine Kinase/RTK
Target
HER2
PDGFR
EGFR, MAPK14
HCV
Influenza Virus
EGFR,HCV,PI4K
MOA
Inhibitor
EGFR inhibitor
Solubility
DMSO: Soluble
Source data
