General
Preferred name
AG 490
Synonyms
Tyrphostin AG 490 ()
AG-490 ()
Tyrphostin B42 ()
Zinc02557947 ()
AG490 ()
(E/Z)-AG490 ()
(E/Z)-Tyrphostin AG490 ()
(E/Z)-Tyrphostin B42 ()
Tyrphostin AG490 ()
AG-490 (Tyrphostin B42) ()
P&D ID
PD002602
CAS
133550-30-8
134036-52-5
Tags
available
drug candidate
obsolete probe
Drug indication
Multiple myeloma
Renal transplantation
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tyrphostin AG 490 is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. Its discovery is reported in where it is compound 44(-).. (GtoPdb)
DESCRIPTION (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 (HY-12000) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
DESCRIPTION AG490 (Tyrphostin AG490) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3.
PRICE 35
DESCRIPTION AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 ??M). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src.
DESCRIPTION Jak-2 protein tyrosine kinase (PTK) inhibitor (LOPAC library)
DESCRIPTION PDE4 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION EGFR-kinase inhibitor. Also JAK2, JAK3 inhibitor (Tocriscreen Total)
DESCRIPTION AG490 (Tyrphostin B42) is an inhibitor of EGFR (IC50: 0.1 μM). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
2
Compound Sets
17
AdooQ Bioactive Compound Library
A10047
Axon Medchem Screening Library
1378
Cayman Chemical Bioactives
10010311
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
DM3WKO5
Guide to Pharmacology
5916
LOPAC library
MedChem Express Bioactive Compound Library
HY-107459
HY-12000
Novartis Chemogenetic Library (NIBR MoA Box)
Obsolete Compounds
ag490
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
AG-490
TargetMol Bioactive Compound Library
T2600
Tocris Bioactive Compound Library
0414
Tocriscreen Total
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
294.1
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
2.32
TPSA
93.35
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
Autophagy
EGFR
JAK
STAT
EGFR, JAK2, JAK3
JAK2 Inhibitor
EGFR,JAK
HER2/ErbB2
Selectivity
JAK2
Pathway
Angiogenesis
Chromatin/Epigenetic
JAK/STAT Signaling
Stem Cells
Tyrosine Kinase/Adaptors
Epigenetics
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
MOA
Inhibitor
Jak3 Inhibitors
STAT-3 Inhibitors
Jak2 Inhibitors
Antiinflammatory Drugs
EGFR inhibitor, JAK inhibitor
Member status
virtual
Source data