General
Preferred name
TIMOLOL MALEATE
Synonyms
S(-)-Timolol maleate ()
(S)-Timolol maleate ()
MK 950 ()
L-714,465 (Maleate) ()
Timolol maleate salt ()
MK 950(S)-Timolol Maleate ()
(S)-Timolol (Maleate) ()
(S)-L-714,465 (maleate) ()
MK-950,(S)-Timolol Maleate ()
Timoptic ()
Timololi maleas ()
Istalol ()
Timoptic Xe ()
WP-934 ()
Timoptic In Ocudose ()
Blocadren ()
Aquanil ()
Ophtamolol ()
Timoptic-XE ()
Timolol hydrogen maleate salt ()
NSC-757351 ()
Timolol (as maleate) ()
Timolol maleate, s-enantiomer ()
Timolol (maleate) ()
P&D ID
PD002597
CAS
26921-17-5
60469-65-0
26839-75-8
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Anti-Adrenergic (beta-receptor)
First approval
1978
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
beta Adrenoceptor antagonist; antihypertensive; antiarrhythmic; antiglaucoma agent
(LOPAC library)
DESCRIPTION
Selective H1 inverse agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
β1 antagonist
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
11
Axon Medchem Screening Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
LOPAC library
MedChem Express Bioactive Compound Library
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
432.17
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
1
cLogP
0.21
TPSA
154.34
Fraction CSP3
0.65
Chiral centers
1.0
Largest ring
6.0
QED
0.42
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
??1-adrenergic receptor
??2-adrenergic receptor
ß blocker
Adrenergic Receptor
Primary Target
Adrenergic ?1 Receptors
MOA
Antagonist
Source data
