General
Preferred name
IMIQUIMOD
Synonyms
IMIQUIMOD HYDROCHLORIDE ()
R 837 ()
IMQ ()
S-26308 ()
R837 maleate ()
R 837 maleate ()
R837 hydrochloride ()
R-837 hydrochloride ()
Imiquimod HCl ()
R 837 hydrochloride ()
Imiquimod 2HCl(99011-02-6 Free base) ()
Imiquimod (Aldara) ()
Imiquimod (hydrochloride) ()
Imiquimod (maleate) ()
R 837 (hydrochloride) ()
Aldara,R-837, S-26308 ()
Imiquimod maleate ()
Imiquimod (R-837) ()
Imiquimod 2HCl ()
ImiquimodAldara1H-Imidazo[4,5-c]quinolin-4-amine, 1-(2-methylpropyl)- ()
Zartra ()
NSC-369100 ()
R-837 ()
Aldara ()
NSC-759651 ()
Tmx-101 ()
Zyclara ()
S26308 ()
Imiqimod ()
Imiquimod-d9 ()
P&D ID
PD002592
CAS
99011-02-6
9050-31-1
99011-78-6
896106-16-4
2995277-02-4
2712126-48-0
Tags
available
drug
Approved by
FDA
EMA
First approval
1997
Drug indication
Skin cancer
Actinic keratosis
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Imiquimod hydrochloride (R 837 hydrochloride), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod hydrochloride exhibits antiviral and antitumor effects in vivo. Imiquimod hydrochloride can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].
PRICE 29
DESCRIPTION Imiquimod is a TLR7 agonist acting as an immunomodulator. (GtoPdb)
PRICE 29
PRICE 29
DESCRIPTION Imiquimod maleate (R 837 maleate), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod maleate exhibits antiviral and antitumor effects in vivo. Imiquimod maleate can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].
PRICE 535
DESCRIPTION Imiquimod hydrochloride is an immune response modifier. It acts as a toll-like receptor 7 agonist. It is commonly used topically to treat warts on the skin of the genital and anal areas. It is also used to treat certain diseases of the skin, including skin cancers, such as basal cell carcinoma, Bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis. It can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system when applied to skin. (BOC Sciences Bioactive Compounds)
DESCRIPTION Imiquimod hydrochloride (R 837 hydrochloride), a selective toll-like receptor 7 (TLR7) agonist, functions as an immune response modifier with in vivo antiviral and antitumor properties, and is utilized in researching external genital and perianal warts, cancer, and COVID-19 [1] [2]. (TargetMol Bioactive Compound Library)
DESCRIPTION Selective ERK inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Caspase 3 activator (LOPAC library)
DESCRIPTION Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. It is used for the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above. (Enamine Bioactive Compounds)
DESCRIPTION Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist. (TargetMol Bioactive Compound Library)
DESCRIPTION Imiquimod maleate is an immune response modifier. It acts as a toll-like receptor 7 agonist. It is commonly used topically to treat warts on the skin of the genital and anal areas. It is also used to treat certain diseases of the skin, including skin cancers, such as basal cell carcinoma, Bowen's disease, superficial squamous cell carcinoma, some superficial malignant melanomas, and actinic keratosis. It can lead to the activation of Langerhans cells, which subsequently migrate to local lymph nodes to activate the adaptive immune system when applied to skin. (BOC Sciences Bioactive Compounds)
DESCRIPTION Imiquimod maleate (R 837 maleate) is a toll-like receptor 7 (TLR7) agonist and immune response modifier with antiviral and antitumor effects. Imiquimod maleate induces psoriatic-like skin lesions in mice and can be used to study various skin malignancies. (TargetMol Bioactive Compound Library)
DESCRIPTION Imiquimod 2HCl is a toll-like receptor 7 (TLR7) agonist and an immunomodulator with antiviral and antitumor activity.Imiquimod 2HCl can be used to construct a psoriasis-like mouse model, which can be used to study periocular skin cancers, pemphigus foliaceus, and COVID-19 infection. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
1
Compound Sets
35
AdooQ Bioactive Compound Library
A10469
Axon Medchem Screening Library
3107
BOC Sciences Bioactive Compounds
imiquimod-hydrochloride-cas-99011-78-6-item-474934
imiquimod-maleate-cas-896106-16-4-item-474895
Cayman Chemical Bioactives
14956
26424
ChEMBL Approved Drugs
CHEMBL1282
ChEMBL Drugs
CHEMBL1282
Concise Guide to Pharmacology 2017/18
5003
Concise Guide to Pharmacology 2019/20
5003
Concise Guide to Pharmacology 2021/22
5003
Concise Guide to Pharmacology 2023/24
5003
Drug Repurposing Hub
DrugBank
DB00724
DrugBank Approved Drugs
DB00724
DrugCentral
1429
DrugCentral Approved Drugs
1429
DrugMAP
DM1TMA3
DrugMAP Approved Drugs
DM1TMA3
DrugMatrix
Enamine Bioactive Compounds
EBC-07888
Enamine BioReference Compounds
Guide to Pharmacology
5003
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1282
MedChem Express Bioactive Compound Library
HY-B0180A
HY-B0180
HY-B0180B
NCATS Inxight Approved Drugs
P1QW714R7M
NIH Approved Oncology Drugs
48426262
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Imiquimod
TargetMol Bioactive Compound Library
T22091
T0134
T22862
T0134L
The Spectrum Collection
Tocris Bioactive Compound Library
3700
Withdrawn 2.0
EMA21
External IDs
65
Properties
(calculated by RDKit )
Molecular Weight
240.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
3
cLogP
2.82
TPSA
56.73
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Casp3
Target
TLR7
antiviral；TLR7
TLR7, TLR8
TLR7/TLR8 agonist
HSV
SARS-CoV
Toll-like Receptor (TLR)
Immunology & Inflammation related
TLR
TLR8
Pathway
Autophagy
Immunology/Inflammation
Microbiology/virology
Anti-infection
Primary Target
Toll-like Receptors
MOA
Agonist
TLR7 Receptor Agonists
Interferon Inducers
interferon inducer, toll-like receptor agonist
Member status
member
Indication
actinic keratosis (AK), genital warts, basal cell carcinoma (BCC)
Disease Area
dermatology, infectious disease, oncology
ATC
D06BB10
L03AX
Therapeutic Class
Antiviral Agents
Solubility
10 mM in DMSO
Source data