General
Preferred name
CYCLAMIC ACID
Synonyms
Calcium cyclamate ()
Cyclohexylsulfamic acid ()
Cyclamate ()
NSC 220327 ()
N-Cyclohexylsulfamic acid ()
Cyclamic acid ()
Hexamic acid ()
INS-952(I) ()
NSC-220327 ()
E-952(I) ()
INS NO.952(I) ()
P&D ID
PD002515
CAS
100-88-9
Tags
available
drug candidate
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cyclamate is a widely used synthetic artificial sweetener. Its use in general food products is banned in several countries. (GtoPdb)
DESCRIPTION Cyclamic acid (Cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5].
PRICE 29
DESCRIPTION Cyclamic acid (NSC-220327) is an artificial sweetening agent, usually employed as Na or Ca salt (cyclamate). Use suspended in some countries, including USA, because of possible weak carcinogenic activity (disputed).
DESCRIPTION Cyclamic acid in the form of its sodium or calcium salt is one of the most widely used artificial sweeteners. (BOC Sciences Bioactive Compounds)
Compound Sets
11
BOC Sciences Bioactive Compounds
n-cyclohexylsulfamic-acid-cas-100-88-9-80790
ChEMBL Drugs
CHEMBL1206440
Concise Guide to Pharmacology 2023/24
12470
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100890
Guide to Pharmacology
12470
MedChem Express Bioactive Compound Library
HY-B0541
NPC Screening Collection
Selleckchem Bioactive Compound Library
cyclamic-acid
The Spectrum Collection
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
179.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
0
cLogP
0.71
TPSA
66.4
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
6.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Necroptosis
Source data