General
Preferred name
ACETAZOLAMIDE
Synonyms
Acetazolamide D3 ()
OT-302 sodium ()
Acetazolamide (sodium) ()
Diamox ()
ACETAZOLAMIDE SODIUM ()
Acetazolamide ()
Atenezo ()
Defiltran ()
Glaupax ()
Phonurit ()
Eytazox ()
Diuriwas ()
Diamox SR ()
Acetazolamida ()
Didoc ()
L 579486 ()
Acetazolamidum ()
Nephramide ()
NSC-145177 ()
Acetamox ()
Edemox ()
Donmox ()
Vetamox ()
Acetazolamide sodium salt ()
Sodium acetazolamide ()
Acetazolamide-d3 ()
P&D ID
PD002491
CAS
59-66-5
5661-25-6
1424-27-7
124442-28-0
1189904-01-5
Tags
available
drug
Approved by
FDA
First approval
1982
1953
Drug indication
Seizure
Glaucoma/ocular hypertension
Kidney disease
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Carbonic anhydrase inhibitor (GtoPdb)
DESCRIPTION Acetazolamide is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].
PRICE 29
DESCRIPTION Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.
PRICE 29
DESCRIPTION Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. Acetazolamide sodium has diuretic, antihypertensive and anti-gonococcal activities[1][4][5][6].
DESCRIPTION Selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Carbonic anhydrase inhibitor; diuretic (LOPAC library)
DESCRIPTION Acetazolamide is a carbonic anhydrase inhibitor. It is effective against absence seizures, useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. (Enamine Bioactive Compounds)
DESCRIPTION Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA)IX inhibitor with diuretic, antigonococcal, and antihypertensive activity and may be used for indications such as epilepsy, glaucoma, edema, and altitude sickness. (TargetMol Bioactive Compound Library)
Cell lines
3
Organisms
4
Compound Sets
33
Cayman Chemical Bioactives
21218
40125
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL20
CHEMBL1200814
ChEMBL Drugs
CHEMBL20
CHEMBL1200814
Concise Guide to Pharmacology 2017/18
6792
Concise Guide to Pharmacology 2019/20
6792
Concise Guide to Pharmacology 2021/22
6792
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00819
DrugBank Approved Drugs
DB00819
DrugCentral
56
DrugCentral Approved Drugs
56
DrugMAP
DM1AF5U
DrugMAP Approved Drugs
DM1AF5U
DrugMatrix
Enamine Bioactive Compounds
EBC-03431
Enamine BioReference Compounds
Guide to Pharmacology
6792
Ki Database
acetazolamide
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL20
MedChem Express Bioactive Compound Library
HY-B0782
HY-B0782A
NCATS Inxight Approved Drugs
O3FX965V0I
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
acetazolamide
TargetMol Bioactive Compound Library
T60351
The Spectrum Collection
Tocris Bioactive Compound Library
6742
External IDs
81
Properties
(calculated by RDKit )
Molecular Weight
221.99
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.86
TPSA
115.04
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
5.0
QED
0.63
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Carbonic anhydrase inhibitor
Inhibitor
Carbonic Anhydrase Type II Inhibitors
Carbonic Anhydrase Type XIII Inhibitors
Carbonic Anhydrase Type VI Inhibitors
Carbonic Anhydrase Type XIV Inhibitors
Carbonic Anhydrase Type XV Inhibitors
Selectivity
Carbonic anhydrase
Target
Carbonic Anhydrase
Carbonic anhydrase XII
Carbonic anhydrase I
Carbonic anhydrase II
Carbonic anhydrase IV
Carbonic anhydrase IX
AQP1, CA1, CA12, CA14, CA2, CA3, CA4, CA7
Autophagy
Bacterial
Pathway
Metabolic Enzyme/Protease
Metabolism
Anti-infection
Primary Target
Carbonic Anhydrases
Member status
member
Indication
glaucoma
Therapeutic Class
Anticonvulsants
Source data