General
Preferred name
ACETOHYDROXAMIC ACID
Synonyms
Methylhydroxamic acid ()
ACETIC ACID ()
Lithostat ()
AHA ()
oxime ()
N-Hydroxyacetamide ()
N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid|oxime, Lithostat ()
N-Hydroxyacetamide, Methylhydroxamic acid, Acetic acid ()
oxime, Lithostat,AHA ()
Acido acetohidroxamico ()
Acide acetohydroxamique ()
NSC-176136 ()
Acetylhydroxamic acid ()
P&D ID
PD002490
CAS
546-88-3
Tags
available
drug
Approved by
FDA
First approval
1983
Drug indication
Urea cycle disorder
Urinary tract infection
Drug Status
approved
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Acetohydroxamic acid is the inhibitor for bacterial and plant urease that can be used for chronic urinary tract infections. Acetohydroxamic acid selectively inhibits arachidonic acid 5-lipoxygenase that is useful in the research of asthma. Acetohydroxamic acid inhibits the formation of advanced glycation end products, and reduces oxidative stress and inflammatory responses. Acetohydroxamic acid exhibits antiviral activity against HIV[1][2][3].
PRICE
29
DESCRIPTION
Acetohydroxamic acid reversibly inhibits the bacterial enzyme urease. It is used to treat urea splitting bacterial infections of the urinary tract.
(Enamine Bioactive Compounds)
DESCRIPTION
Acetohydroxamic acid (N-Hydroxyacetamide) is an antagonist of the bacterial enzyme urease.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
21
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
47
Molecular Weight
75.03
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.49
TPSA
49.33
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.3
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
bacterial urease inhibitor
urease inhibitor
Target
Urease subunit alpha
Bacterial urease
Bacterial
MMP
MMP12
HIV
Indication
urinary tract infections
Therapeutic Class
Antiinfective Agents
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Source data
