General
Preferred name
ACETYLCYSTEINE
Synonyms
N-acetyl-L-Cysteine ()
LNAC ()
NAC ()
Acetylcysteine magnesium ()
Acetylcysteine zinc ()
Nacystelyn ()
N-Acetylcysteine ()
Acetylcysteine (N-acetylcysteine) ()
NSC-111180 ()
N-acetyi-l-cysteine ()
Mucosil ()
Airbron ()
Fabrol ()
Fluimucil Long ()
Cetylev ()
N-Acetyl-L-Cysteine ()
Acetadote ()
Oristar nalc ()
Fluimicil ()
Rk-0202 ()
OroNAC 600 ()
Siran ()
Yournac ()
Broncholysin ()
Tixair ()
A-CYS ()
Respi-Nac ()
Mucomyst ()
Solmucol ()
5052 ()
Syntemucol ()
Fluimucil N ()
Mucosil-10 ()
Parvolex ()
Fluimucil ()
ACC-600 ()
Fluimucil 600 ()
Mercapturic acid ()
Ilube ()
Mucosil-20 ()
EN-CYS ()
Respaire ()
Acetyl cysteine ()
Fluimucetin ()
P&D ID
PD002488
CAS
616-91-1
91918-35-3
Tags
drug candidate
natural product
drug
available
Approved by
PMDA
FDA
First approval
1963
Drug Status
experimental
investigational
approved
Max Phase
Phase 4
Drug indication
Mucolytic
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose. It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine likely protects the liver by maintaining or restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite.; ;
DESCPRITION The N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to have antiviral effects in patients with HIV due to inhibition of viral stimulation by reactive oxygen intermediates.
TOXICITY Single intravenous doses of acetylcysteine at 1000 mg/kg in mice, 2445 mg/kg in rats, 1500 mg/kg in guinea pigs, 1200 mg/kg in rabbits and 500 mg/kg in dogs were lethal. Symptoms of acute toxicity were ataxia, hypoactivity, labored respiration, cyanosis, loss of righting reflex and convulsions. ; ;
DESCRIPTION Acetylcysteine is a prodrug for L-cysteine synthesis, and L-cysteine is a precursor to the biologic antioxidant glutathione. Hence adminstration of acetylcysteine replenishes glutathione stores. (GtoPdb)
DESCRIPTION Amino acid analog that partially improves neuronal survival following transient forebrain ischemia (LOPAC library)
Compound Sets
22
AdooQ Bioactive Compound Library
A10032
Cayman Chemical Bioactives
20261
ChEMBL Approved Drugs
CHEMBL600
ChEMBL Drugs
CHEMBL600
Drug Repurposing Hub
DrugBank
DB06151
DB14080
DB14479
DB17839
DrugBank Approved Drugs
DB06151
DrugCentral
66
DrugCentral Approved Drugs
66
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100385
Guide to Pharmacology
10945
JUMP-Target 1 Compound Set
12035
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0215
NCATS Inxight Approved Drugs
WYQ7N0BPYC
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
acetylcysteine
TargetMol Bioactive Compound Library
T0875
The Spectrum Collection
External IDs
87
Properties
(calculated by RDKit )
Molecular Weight
163.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.49
TPSA
66.4
Fraction CSP3
0.6
Chiral centers
1.0
Largest ring
0.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Immunology/Inflammation
Apoptosis
Protein Tyrosine Kinase/RTK
Anti-infection
Metabolic Enzyme/Protease
NF-κB
Target
ROS
TNF-??
TNF-¦Á
ACY1, CHUK, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIN3A, GSS, IKBKB, RELA, SLC7A11
SLC7A11
Endogenous Metabolite
Ferroptosis
Influenza Virus
Reactive Oxygen Species
Antiviral,Apoptosis related,Ferroptosis,NF-¦ÊB,ROS,TNF-alpha
MOA
TNF
mucolytic agent
Indication
acetaminophen overdose, hepatic injury
Source data