General
Preferred name
adenosine
Synonyms
Adenocard ()
Adenosine ()
9-.BETA.-D-RIBOFURANOSYLADENINE ()
ADENOCOR ()
SR 96225 ()
NSC-7652 ()
Adenoscan ()
SR-96225 ()
P&D ID
PD002487
CAS
58-61-7
46946-45-6
30143-02-3
142796-17-6
5536-17-4
Tags
available
drug
Approved by
FDA
First approval
1989
Drug indication
Paroxysmal supraventricular tachycardia
Pain
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Endogenous nucleoside, a component of nucleic acids and an important neurotransmitter.
(GtoPdb)
DESCRIPTION
Selective calcium-sensing receptor (CaSR) antagonist; orally active calcilytic agent
(Tocris Bioactive Compound Library)
DESCRIPTION
Adenosine is a medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia. It is an agonist of adenosine receptors A1 and A2.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
3
Organisms
3
Compound Sets
28
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
Natural product-based probes and drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Selleckchem Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
267.1
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
2
cLogP
-1.98
TPSA
139.54
Fraction CSP3
0.5
Chiral centers
4.0
Largest ring
6.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Non-selective Adenosine
MOA
Agonist
Adenosine Receptor Agonists
Adenosine Receptor agonist
Member status
virtual
Target
ADORA1, ADORA2A, ADORA2B, ADORA3, PI4K2A, PI4K2B, TRPM4
Adenosine Receptor,Nucleoside Analog/Antimetabolite
Indication
Wolff-Parkinson-White Syndrome (WPW)
Biosynthetic Origin
Nucleoside
Therapeutic Indication
Antiarrhythmic
Therapeutic Class
Cardiovascular
Antiarrhythmic Agents
Recommended Cell Concentration
1 uM
Source data
