General
Preferred name
AMANTADINE HYDROCHLORIDE
Synonyms
1-Adamantylamine hydrochloride ()
CI-719 ()
1-Adamantanamine hydrochloride ()
Amantadine HCl ()
1-adamantanamine HCl ()
Symmetrel ()
1-Aminoadamantane hydrochloride ()
Amantadine (hydrochloride) ()
Gocovri ()
Lysovir ()
Mantadix ()
Osmolex ()
Adamantanamine hydrochloride ()
Mantadine ()
Symadine ()
EXP-105-1 ()
Osmolex er ()
NSC-83653 ()
P&D ID
PD002484
CAS
665-66-7
768-94-5
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Antiviral
First approval
1968
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dopamine releaser used in the treatment of Parkinsonism and drug-;related extrapyramidal reactions; antiviral (Influenza A) (LOPAC library)
Cell lines
0
Organisms
3
Compound Sets
10
ChEMBL Approved Drugs
CHEMBL1569
ChEMBL Drugs
CHEMBL1569
CZ-OPENSCREEN Bioactive Library
Enamine BioReference Compounds
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0402A
NIH Clinical Collections (NCC)
Selleckchem Bioactive Compound Library
Amantadine-hydrochloride(Symmetrel)
TargetMol Bioactive Compound Library
T1406
The Spectrum Collection
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
187.11
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
2.34
TPSA
26.02
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Anti-infection
Apoptosis
Cell Cycle/DNA Damage
Target
dopamine
Bcl-2 Family
CDK
Influenza Virus
Orthopoxvirus
SARS-CoV
Dopamine Receptor
Source data