General
Preferred name
AMINOGLUTETHIMIDE
Synonyms
Aminoglutethimide phosphate, monohydrochloride ()
(±)-p-Aminoglutethimide ()
BA-16038 ()
NSC-330915 ()
DL-Aminoglutethimide ()
Glutethimide, para-amino ()
Orimeten ()
Cytadren ()
P&D ID
PD002479
CAS
125-84-8
Tags
natural product
drug
available
Approved by
FDA
First approval
1980
Drug Status
investigational
approved
withdrawn
Drug indication
Antineoplastic
Cushing disease
Adrenocortical Suppressant
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Aminoglutethimide is an aromatase (CYP19A1) and steroid 11β-hydroxylase (CYP11A1) inhibitor.
(GtoPdb)
DESCRIPTION
.;Inhibits Cytochrome P450-dependent hydroxylation reactions that are necessary for aromatization
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
25
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
LOPAC library
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
232.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
1
cLogP
1.35
TPSA
72.19
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
P450-dependendent hydroxylation
Pathway
Endocrinology/Hormones
Target
Aromatase
Member status
member
MOA
Aromatase Inhibitors
Antiglucocorticoids
ATC
L02BG01
Toxicity type
multiple
Therapeutic Class
Anticancer Agents
Source data
