General
Preferred name
AMITRIPTYLINE HYDROCHLORIDE
Synonyms
Amitriptyline HCl ()
Annoyltin ()
Tryptizol ()
Domical ()
Amitriptyline (HCl) ()
Amitryptiline hydrochloride ()
Amitriptyline (hydrochloride) ()
Elavil ()
Amitid ()
Triptafen ()
Amitril ()
Saroten ()
Limbitrol 5 ()
NSC-104210 ()
Endep ()
Triptafen-M ()
Amitriptylini hydrochloridum ()
Lentizol ()
Saroten Retard ()
Syneudon ()
NIH 10794 ()
Cytriptyline ()
Tryptizol-75 ()
Etravil ()
Novoprotect ()
Amitriptyline (hydrochloride) (CRM) ()
P&D ID
PD002477
CAS
549-18-8
Tags
nuisance
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antidepressant
First approval
1961
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tricyclic antidepressant
(LOPAC library)
DESCRIPTION
Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
13
ChEMBL Approved Drugs
ChEMBL Drugs
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
23
Molecular Weight
313.16
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
4.59
TPSA
3.24
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
7.0
QED
0.8
Structural alerts
3
styrene_A(13)
[#6]-2-[#6]-c:1:c(:c:c:c:c:1)-[#6](-c:3:c:c:c:c:c-2:3)=[#6]-[#6]
PAINS Family C
historic compounds (Chemical Probes.org)
Obsolete
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Membrane Transporter/Ion Channel
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Target
5-HT
5-HT2
5-HT4
Norepinephrine receptor
??1
5-HT Receptor
Adrenergic Receptor
Histamine Receptor
mAChR
Serotonin Transporter
Sodium Channel
Trk Receptor
5-HT Receptor,Histamine Receptor,Serotonin Transporter
Primary Target
5-HT Transporters
MOA
Inhibitor
Source data
