General
Preferred name
ANTAZOLINE
Synonyms
ANTAZOLINE HYDROCHLORIDE ()
Phenazocine HCl ()
Phenazoline hydrochloride ()
Antazoline HCl ()
Antazoline ()
ANTAZOLINE PHOSPHATE ()
Antazoline (hydrochloride) ()
Phenazoline (hydrochloride) ()
Phenazoline ()
Argireline ()
Antazolina ()
Atazoline ()
Vasocon-A ()
Antaz Sulf ()
R.B.C. ()
Antaz HCl ()
Antazoline phosphate component of vasocon-a ()
NSC-755865 ()
P&D ID
PD002471
CAS
91-75-8
2508-72-7
154-68-7
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1994
1990
Drug indication
Nasal congestion
pterygium
Drug Status
approved
withdrawn
investigational
Max Phase
3.0
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION There is no information regarding approval for clinical use of this drug on the US FDA website. Other national approval agencies may have granted marketing authorisation. (GtoPdb)
DESCRIPTION Antazoline (Phenazoline) is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect[1][2][3].
PRICE 29
PRICE 32
DESCRIPTION Antazoline (Phenazoline) hydrochloride is a first-generation antihistamine that also has anticholinergic properties and is used to relieve nasal congestion and is also used as eye drops.
DESCRIPTION Antazoline hydrochloride (Phenazoline hydrochloride), a first-generation antihistamine, can bind to the histamine H1 receptor and block the action of endogenous histamine. (TargetMol Bioactive Compound Library)
DESCRIPTION Antazoline has antihistamine and anticholinergic effects.It used to treat a variety of arrhythmias. (TargetMol Bioactive Compound Library)
DESCRIPTION Imidazoline ligand (Tocriscreen Total)
DESCRIPTION Antazoline HCl is a first generation antihistamine, binding to the histamine H1 receptor and blocking the action of endogenous histamine. (BOC Sciences Bioactive Compounds)
DESCRIPTION Antazoline hydrochloride is a 1st generation antihistamine with also anticholinergic properties. It is used to relieve nasal congestion and in eye drops, usually in combination with naphazoline, to relieve the symptoms of allergic conjunctivitis. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
25
BOC Sciences Bioactive Compounds
antazoline-hydrochloride-cas-2508-72-7-item-84-64111
Cayman Chemical Bioactives
23415
ChEMBL Approved Drugs
CHEMBL1305
CHEMBL1200550
ChEMBL Drugs
CHEMBL1305
CHEMBL1256819
CHEMBL1200550
Drug Repurposing Hub
DrugBank
DB08799
DrugBank Approved Drugs
DB08799
DrugCentral
224
DrugCentral Approved Drugs
224
DrugMAP
DMA04JS
DrugMAP Approved Drugs
DMA04JS
DrugMatrix
Enamine Bioactive Compounds
EBC-03693
Enamine BioReference Compounds
Guide to Pharmacology
7116
Ki Database
Antazoline
MedChem Express Bioactive Compound Library
HY-B1067A
HY-B1067
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
argireline
antazoline-phosphate
TargetMol Bioactive Compound Library
T0092
T7477
The Spectrum Collection
Tocriscreen Total
Withdrawn 2.0
544
External IDs
68
Properties
(calculated by RDKit )
Molecular Weight
265.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
2.69
TPSA
27.63
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.9
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Anti-infection
Neuronal Signaling
Disease Area
ophthalmology, otolaryngology
Indication
conjunctivitis, nasal congestion
Target
HRH1
HBV
Histamine Receptor
H1 receptor
MOA
antihistamine
ATC
R01AC04
R06AX05
Solubility
Soluble in DMSO (Slightly, Heated), Methanol (Slightly)
Source data