General
Preferred name
BENZOCAINE
Synonyms
benzocaine, Arbor Pharmaceuticals ()
Benzocaine (hydrochloride) ()
ethyl 4-aminobenzoate ()
Ethyl 4-aminobenzoate hydrochloride, Benzocaine HCl, Ethyl p-aminobenzoate hydrochloride ()
Benzocaine hydrochloride ()
Ethyl Aminobenzoate ()
Anthisan Plus ()
Tyrozets ()
AR-01 ()
Orajel ()
Children's Chloraseptic ()
Aezodent ()
Anaesthesin ()
Benzocaina ()
Lanacane ()
Ethyl paba ()
Medilave ()
Ethyl p-aminobenzoate ()
Americaine ()
Burneze ()
Parathesin ()
Flavamed ()
Dequacaine ()
Norcaine ()
Subcutin ()
Nestosyl ()
Tyrosolven ()
AR01 ()
Benzocainum ()
NSC-41531 ()
Baby anbesol ()
Parathesine ()
Ethyl para-amino benzoate ()
NSC-4688 ()
P&D ID
PD002459
CAS
94-09-7
71123-91-6
1333-08-0
23239-88-5
Tags
available
drug
Approved by
FDA
Drug indication
Pruritus
Anaesthesia
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION Benzocaine (hydrochloride) is an orally active local agent that can suppress or relieve pain, that acts on voltage-gated Na+ channels at a common receptor, with an IC50 value of 0.8 mM at +30 mV. Additionally, Benzocaine (hydrochloride) non-competitively inhibits Ca-ATPase binding with Ca2+, with an IC50 of 47.1 mM. Benzocaine (hydrochloride) can be used in research within the field of neuromuscular regulation[1][2][3].
DESCRIPTION Benzocaine is a topical local anesthetic used for the temporary relief of pain and itching associated with minor burns, sunburn, scrapes and insect bites or minor skin irritations. (Enamine Bioactive Compounds)
DESCRIPTION Benzocaine is a surface anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. (TargetMol Bioactive Compound Library)
Compound Sets
21
Cayman Chemical Bioactives
20132
ChEMBL Drugs
CHEMBL278172
Drug Repurposing Hub
DrugBank
DB01086
DrugBank Approved Drugs
DB01086
DrugCentral
323
DrugCentral Approved Drugs
323
DrugMAP
DMI18HW
DrugMAP Approved Drugs
DMI18HW
DrugMatrix
Enamine Bioactive Compounds
EBC-13558
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-Y0258
HY-Y0258A
NCATS Inxight Approved Drugs
U3RSY48JW5
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
benzocaine
benzocaine-hydrochloride
TargetMol Bioactive Compound Library
T0924
The Spectrum Collection
VGSC-DB
NA5918
NA5919
External IDs
66
Properties
(calculated by RDKit )
Molecular Weight
165.08
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
1
Aromatic Ring Count
1
cLogP
1.45
TPSA
52.32
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
LCE 1
MRP1
Sodium Channel
SCN10A
Bacterial
Indication
first-aid antiseptic
MOA
Sodium Channel blocker
Therapeutic Class
Anesthetics
VGSC Target
Nav1.9
Pathway
Immunology/Inflammation
Membrane Transporter/Ion Channel
Anti-infection
Source data