General
Preferred name
BETA CAROTENE
Synonyms
beta-CAROTENE [2mM] ()
betacarotene ()
¦Â-Carotene ()
Provitamin A ()
??-Carotene ()
Carotaben ()
beta-carotene ()
β,β-Carotene, Provitamin A, Solatene, β-Carotene ()
??Carotene ()
????Carotene, Provitamin A, Solatene, ??Carotene ()
β-Carotene ()
B-Carotene ()
All-trans-.beta.-carotene ()
Solatene ()
Optimun ()
Ins-160a(iii) ()
Rovimix .beta.-carotene ()
Provatene ()
Serlabo ()
Lumitene ()
Carotene,beta ()
Golden Rose ()
Ci 40800 ()
NSC-62794 ()
Lucaratin ()
C.I.-40800 ()
Ci 75130 ()
Betacarotene ()
Ins no.160a(iii) ()
Food orange 5 ()
Caroten base 35468 ()
Optimum ()
Beta, beta-carotene ()
E-160a(iii) ()
Gerard ()
Ci food orange 5 ()
BetaVit ()
Provatenol ()
Nature's Plus ()
Beta,beta-carotene ()
.beta.-carotene ()
Eldon ()
Lucarotin 30sun ()
.beta.-Carotene ()
P&D ID
PD002456
CAS
7235-40-7
Tags
nuisance
natural product
drug
available
Approved by
FDA
Drug Status
nutraceutical
approved
withdrawn
Drug indication
Vitamin deficiency
Ultraviolet Screen
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ABSORPTION After administration of beta-carotene, some of the administered dose is absorbed into the circulatory system unchanged and stored in the fat tissue. The coadministration of beta-carotene and a high-fat content diet is correlated to a better absorption of beta-carotene. The absorption is also dependent on the isomeric form of the molecule where the cis conformation seems to present a higher bioavailability. The absorption of beta-carotene is thought to be performed in 6-7 hours.[L2202]; ; The reported AUC of beta-carotene when administered orally from 0 to 440 hours after initial administration was reported to be 26.3 mcg.h/L. The maximal concentration of beta-carotene is attained in a dual pharmacokinetic profile after 6 hours and again after 32 hours with a concentration of 0.58 micromol/L.[A32488]
PHARMACODYNAMICS Oral administration of beta-carotene increases the serum concentration of beta-carotene by 60% but it does not change the concentration found in the heart, liver or kidneys.[T159] In vitro studies in hepatocytes have shown that beta-carotene ameliorates oxidative stress, enhances antioxidant activity and decreases apoptosis.[T161]; ; Other than the antioxidant activities, some other actions have been correlated to beta-carotene. It is thought to have detoxifying properties, as well as to help increase resistance to inflammation and infection and increase immune response and enhance RNA production.[L2202]
MOA Beta-carotene is an antioxidant that presents significant efficacy against the reactive oxygen species singlet oxygen.[T159] Beta-carotene acts as a scavenger of lipophilic radicals within the membranes of every cell compartments. It also presents an oxidative modification of LDL.[T160] The presence of long chains of conjugated double bonds is responsible for its antioxidative properties by allowing beta-carotene to chelate oxygen-free radicals and dissipate their energy.[T162] The chelation of free radicals inhibits the peroxidation of lipids.[T163]; ; The effect of beta-carotene in the immune response is thought to be related to the direct effect on the thymus which increases the production of immune cells.[L2202]
INDICATION Beta-carotene is FDA approved to be used as a nutrient supplement and to be even added in infant formula as a source of vitamin A.[L2191] It is also approved to be used as a color additive for food products,[L2192] drugs (with the label of "only as a color additive")[L2193] and cosmetics.[L2194]; ; It is used commonly for the reduction of photosensitivity in patients with erythropoietic protoporphyria and other photosensitivity diseases.[A32485]
Cell lines
0
Organisms
2
Compound Sets
18
AdooQ Bioactive Compound Library
A10128
Cayman Chemical Bioactives
16837
ChEMBL Approved Drugs
CHEMBL1293
ChEMBL Drugs
CHEMBL1293
Drug Repurposing Hub
DrugBank
DB06755
DrugBank Approved Drugs
DB06755
DrugCentral
345
DrugCentral Approved Drugs
345
DrugMAP
DM0RXBT
DrugMAP Approved Drugs
DM0RXBT
MedChem Express Bioactive Compound Library
HY-N0411
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
TargetMol Bioactive Compound Library
T1633
The Spectrum Collection
Withdrawn 2.0
1380
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
536.44
Hydrogen Bond Acceptors
0
Hydrogen Bond Donors
0
Rotatable Bonds
10
Ring Count
2
Aromatic Ring Count
0
cLogP
12.61
TPSA
0.0
Fraction CSP3
0.45
Chiral centers
0.0
Largest ring
6.0
QED
0.24
Structural alerts
1
Singlet oxygen quenching
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Apoptosis
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Target
VA
Endogenous Metabolite
Reactive Oxygen Species
MOA
Vitamin inhibitor
ATC
A11CA02
D02BB01
Source data