General
Preferred name
CARBACHOL
Synonyms
Carbamylcholine chloride ()
Carbamoylcholine chloride ()
Carbachol Cl- ()
CARBACHOL CHLORIDE ()
Doryl ()
Carbacol ()
NSC-32865 ()
Miostat ()
Carbastat ()
P&D ID
PD002446
CAS
51-83-2
Tags
available
drug
Drug indication
presbyopia
Glaucoma/ocular hypertension
Drug Status
approved
Max Phase
4.0
First approval
1972
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Carbachol (Carbamoylcholine chloride), an analog of acetylcholine, serves as a valuable tool in the investigation of various physiological responses mediated by nicotinic (nAChR) and muscarinic (mAChR) acetylcholine receptors. These responses include smooth muscle contraction, gut motility, and neuronal signaling. Known for its agonistic properties, Carbachol activates both nAChR and mAChR, with reported Ki values ranging from 10 to 10,000 nM for different receptor types and experimental preparations.
DESCRIPTION
Carbamoylcholine is an analog of acetylcholine that activates acetylcholine receptors (AChR). Carbachol is a direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery.
(Enamine Bioactive Compounds)
DESCRIPTION
Acetylcholine receptor agonist
(LOPAC library)
DESCRIPTION
nAChR antagonist
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
2
Compound Sets
17
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
Prestwick Chemical Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
182.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-3.21
TPSA
52.32
Fraction CSP3
0.83
Chiral centers
0.0
Largest ring
0.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Nicotinic Receptors (Non-selective)
MOA
Agonist
Therapeutic Class
Cardiotonic Agents
Source data
