General
Preferred name
CEFAZOLIN SODIUM
Synonyms
Ancef ()
Cefazolin sodium salt ()
Sodium cephazolin ()
cephazolin sodium ()
cefazoline sodium ()
Sodium cefazolin ()
Cefazolin (sodium) ()
Cephazolin (sodium) ()
cefazoline sodium, cephazolin sodium, Ancef ()
CEFAZOLIN ()
Cefazolin (sodium salt) ()
Cefazil ()
Cefamedin ()
Cefazolin injection ()
SK&F 41558 ()
Totacef ()
SK&F-41558 ()
Cefazolin and dextrose ()
Gramaxin ()
Cefamezin ()
Kefzol ()
Zolicef ()
Acef ()
46083 ()
NSC-291561 ()
Cefacidal ()
P&D ID
PD002440
CAS
27164-46-1
25953-19-9
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Endocarditis
First approval
1973
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cefazolin sodium is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].
PRICE 29
DESCRIPTION Cefazolin sodium is a broad-spectrum first-generation cephalosporin antibiotic. (Enamine Bioactive Compounds)
DESCRIPTION Semi-synthetic antibiotic; interferes with cell wall synthesis (LOPAC library)
DESCRIPTION Cefazolin sodium (cephazolin sodium) salt binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Cefazolin sodium salt is the sodium salt of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, which results in the weakening of the bacterial cell wall and cell lysis. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
13
Cayman Chemical Bioactives
15776
ChEMBL Approved Drugs
CHEMBL1200523
ChEMBL Drugs
CHEMBL1200523
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EBC-08481
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100569
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1078
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
cefazolin-sodium
TargetMol Bioactive Compound Library
T0953
The Spectrum Collection
External IDs
22
Properties
(calculated by RDKit )
Molecular Weight
476.01
Hydrogen Bond Acceptors
13
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
2
cLogP
-4.97
TPSA
158.92
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.23
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Cell wall synthesis
Target
antibiotic
Bacterial
PBPs
Peptidoglycan synthase
PON
Antibiotics,Bacterial
Pathway
Microbiology/virology
Anti-infection
Source data