General
Preferred name
CHLORAMBUCIL
Synonyms
PEPSTATIN ()
CB-1348 ()
Chloroambucil ()
WR-139013 ()
ChlorambucilLeukeranAmbochlorinPhenylbutyric acid nitrogen mustard4-[Bis(2-chloroethyl)amino]phenylbutyric acidp-(N,N-Di-2-chloroethyl)aminophenyl butyric acidCB 1348ElcorilEclorilCb l348 ()
Chlorambucil,CB-1348,WR-139013 ()
Lympholysin ()
NSC-3088 ()
Chlorambucilum ()
Ecloril ()
NCI-3088 ()
Clorambucilo ()
Leukeran ()
Ambochlorin ()
Chlorambucil-d8 ()
P&D ID
PD002434
CAS
305-03-3
2748247-26-7
Tags
available
drug
Approved by
FDA
First approval
1957
Drug indication
Chronic lymphocytic leukaemia
acute lymphoblastic leukemia
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Chlorambucil is a DNA alkylating agent.
(GtoPdb)
DESCRIPTION
Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin¡¯s disease[1][2][3][4].
PRICE
29
DESCRIPTION
DNA alkylator
(Informer Set)
DESCRIPTION
DNA crosslinker; induces apoptosis
(LOPAC library)
DESCRIPTION
Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
58
Organisms
2
Compound Sets
28
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
Informer Set
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Approved Oncology Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
116
Molecular Weight
303.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
1
Aromatic Ring Count
1
cLogP
3.38
TPSA
40.54
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
1
Genotoxic
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Compound status
FDA
MOA
DNA alkylator
DNA inhibitor
Target
DNA
DNA alkylation
DNA alkylator/crosslinker
DNA/RNA Synthesis
Indication
chronic lymphocytic leukemia (CLL), Hodgkin's lymphoma
Therapeutic Class
Anticancer Agents
Pathway
Cell Cycle/DNA Damage
DNA Damage/DNA Repair
Source data
