General
Preferred name
CHLOROTHIAZIDE
Synonyms
Diuril ()
Chlorothiazid ()
Chlotride ()
CHLOROTHIAZIDE SODIUM ()
Saluric ()
Hydrochlorothiazide impurity, chlorothiazide- ()
Chlorthiazide ()
NSC-25693 ()
Chlorothiazide sodium salt ()
P&D ID
PD002427
CAS
58-94-6
7085-44-1
Tags
natural product
drug
available
Approved by
FDA
First approval
1958
Drug Status
approved
vet_approved
Drug indication
Congestive heart failure
Diuretic,Diuretic
Antihypertensive
Diuretic
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chlorothiazide is a thiazide diuretic, similar to hydrochlorothiazide. (GtoPdb)
DESCRIPTION Carbonic anhydrase inhibitor; diuretic; antihypertensive (LOPAC library)
Compound Sets
28
Cayman Chemical Bioactives
17909
26300
ChEMBL Approved Drugs
CHEMBL842
CHEMBL1200616
ChEMBL Drugs
CHEMBL842
CHEMBL1200616
Concise Guide to Pharmacology 2017/18
4835
Concise Guide to Pharmacology 2019/20
4835
Concise Guide to Pharmacology 2021/22
4835
Concise Guide to Pharmacology 2023/24
4835
Drug Repurposing Hub
DrugBank
DB00880
DrugBank Approved Drugs
DB00880
DrugCentral
609
DrugCentral Approved Drugs
609
DrugMAP
DMLHESP
DrugMAP Approved Drugs
DMLHESP
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
4835
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0224
NCATS Inxight Approved Drugs
77W477J15H
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Chlorothiazide(Diuril)
TargetMol Bioactive Compound Library
T0677
The Spectrum Collection
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
294.95
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.06
TPSA
118.69
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.75
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Carbonic anhydrase
Pathway
Metabolism
Target
Carbonic Anhydrase
CA1, CA2, CA4, SLC12A3
Member status
virtual
MOA
SLC12A3 inhibitor
CA1 inhibitor
CA2 inhibitor
CA4 inhibitor
diuretic
Indication
hypertension
Therapeutic Class
Antihypertensive Agents
Source data