General
Preferred name
CHLOROXYLENOL
Synonyms
Phenosept ()
4-Chloro-3,5-dimethylphenol ()
5-dimethylphenol ()
4-Chloro-3-xylenol ()
PCMX ()
p-chloro-m-xylenol ()
Parachlorometoxylenol ()
NSC-4971 ()
Cloroxilenol ()
P&D ID
PD002426
CAS
88-04-0
94021-48-4
Tags
available
drug
Approved by
FDA
Drug Status
approved
investigational
Max Phase
2.0
Drug indication
Inflammation
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
TOXICITY As chloroxylenol is predominantly employed as an active ingredient in various liquids or creams as cleaners, disinfectants, or antiseptics that are generally designed to be used topically, it is widely accepted that the use of such liquids - when used appropriately - is unlikely to present a sufficient volume that could be ingested to cause any medical problems [L1992]. In the event of accidental eye contact, was with Luke warm water [L1992].; ; Chloroxylenol is known to have a low systemic toxicity, even at dosage levels many times higher that those likely to be absorbed during normal usage of the agent [L1999].
ABSORPTION No chloroxylenol was detected in the blood following the dermal administration of 2 g of p-chloroxylenol in an ethanol/olive oil vehicle in human subjects [A32349]. After a dose of 5 g, only traces were found, after 8 g, 1 mg % (1 mg/dL) was found in the blood after 3 hours, and 4 mg % (4 mg/dL) after 24 hours [A32349]. After a dose of 20 g, 4 mg % (4 mg/dL) was measured after half an hour, and 1 mg % (1 mg/dL) was present at 72 hours [A32349].; ; For antiseptic purposes, chloroxylenol is considered to be well-absorbed when applied to the skin [L1999].
METABOLISM Certain animal studies have shown that following dermal application of chloroxylenol, that the absorption was rapid with a Cmax = 1-2 hours, and that the administered substance was excreted via the kidney with almost complete elimination within 24 hours [L1992]. The primary metabolites discovered in the excreted urine were glucuronides and sulfates [L1992]. Some chloroxylenol monographs liken its pharmacokinetic profile to that of another antiseptic - triclosan - which is rapidly excreted in the urine also as a glucuronide metabolite, as observed in the human model [L1992].; ; Moreover, In one human subject administered 5 mg intragluteally, 14% was excreted with glucuronic acid and 17% with sulfuric acid at 3 days [A32350].; ; Any chloroxylenol absorbed into the body is likely extensively metabolized by the liver and rapidly excreted, mainly in the urine, as sulphate and glucuronide conjugates [L1999].
DESCRIPTION Chloroxylenol is a broad-spectrum antibacterial agent that can be used to control bacteria, algae, fungi and viruses[1][2].
PRICE 29
DESCRIPTION Chloroxylenol is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. It is used in antibacterial soaps, wound-cleansing applications, and household antiseptics. The halophenol is shown to be most effective against Gram positive bacteria where it disrupts the cell wall due to its phenolic nature. (Enamine Bioactive Compounds)
DESCRIPTION Chloroxylenol (PCMX) (4-chloro-3, 5-dimethylphenol), a broad spectrum antimicrobial chemical compound, is used to control virus, bacteria, fungi, and algae. It is used in households and hospitals for sanitation and disinfection. (TargetMol Bioactive Compound Library)
Compound Sets
17
AdooQ Bioactive Compound Library
A16004
ChEMBL Drugs
CHEMBL398440
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB11121
DrugBank Approved Drugs
DB11121
DrugCentral
3094
DrugCentral Approved Drugs
3094
DrugMatrix
Enamine Bioactive Compounds
EBC-04299
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
HY-B1414
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
chloroxylenol
TargetMol Bioactive Compound Library
T0898
The Spectrum Collection
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
156.03
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
1
Aromatic Ring Count
1
cLogP
2.66
TPSA
20.23
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.61
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
antibiotic
Bacterial
Influenza Virus
Parasite
Antiviral,Bacterial
Indication
skin infections
MOA
ATP synthase inhibitor
Pathway
Microbiology/virology
Anti-infection
Source data