General
Preferred name
CHLORPROPAMIDE
Synonyms
1-(4-chlorobenzenesulfonyl)-3-propylurea ()
Glymese ()
NSC-44634 ()
Diabemide ()
Glucamide ()
Diabinese ()
Melitase ()
NSC-626720 ()
Clorpropamida ()
P&D ID
PD002423
CAS
94-20-2
Tags
available
drug
Approved by
FDA
First approval
1958
Drug indication
diabetes mellitus
Non-insulin dependent diabetes
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION A sulfonylurea family drug inhibiting sulfonylurea receptor 1 (ABCC8)/Kir6.2 (KCNJ11) (GtoPdb)
DESCRIPTION Chlorpropamide is an oral hypoglycemic agent that can influence acetaldehyde metabolism in mice and has a potentiating effect on antidiuretic hormone[1][2][3][4].
PRICE 29
DESCRIPTION Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.
DESCRIPTION Stimulates insulin release (LOPAC library)
DESCRIPTION Chlorpropamide is a drug in the sulfonylurea class used to treat type 2 diabetes mellitus. It is a long-acting 1st generation sulfonylurea. (BOC Sciences Bioactive Compounds)
DESCRIPTION Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide binds to ATP-sensitive potassium channels on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. (Enamine Bioactive Compounds)
DESCRIPTION PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) (TargetMol Bioactive Compound Library)
Compound Sets
24
BOC Sciences Bioactive Compounds
chlorpropamide-cas-94-20-2-item-84-401957
Cayman Chemical Bioactives
26087
ChEMBL Approved Drugs
CHEMBL498
ChEMBL Drugs
CHEMBL498
Drug Repurposing Hub
DrugBank
DB00672
DrugBank Approved Drugs
DB00672
DrugCentral
622
DrugCentral Approved Drugs
622
DrugMAP
DMPHZQE
DrugMAP Approved Drugs
DMPHZQE
DrugMatrix
Enamine Bioactive Compounds
EBC-26409
EU-OPENSCREEN Bioactive Compound Library
EOS100336
Guide to Pharmacology
6801
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1429
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
chlorpropamide
TargetMol Bioactive Compound Library
0772-0015
The Spectrum Collection
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
276.03
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
1
Aromatic Ring Count
1
cLogP
1.74
TPSA
75.27
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Insulin
Target
ABCC8, KCNJ10
Na+/K+ ATPase
ATPase
Indication
diabetes mellitus
MOA
ATP channel blocker
Therapeutic Class
Hypoglycemic Agents
Pathway
Membrane Transporter/Ion Channel
Source data