General
Preferred name
CHLORZOXAZONE
Synonyms
Chlorzoxazon ()
Paraflex ()
Chlorzoxazon,Paraflex ()
Parafon ()
Strifon ()
Parafon Forte Dsc ()
Strifon Forte Dsc ()
NSC-26189 ()
Parafon-Forte ()
Parafon Forte ()
Chlorzoxazone-d3 ()
P&D ID
PD002420
CAS
95-25-0
32850-84-3
1185173-60-7
Tags
natural product
drug
available
Approved by
FDA
First approval
1958
Drug Status
approved
Drug indication
Acute pain
Relaxant (skeletal muscle)
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chlorzoxazone acts on the central nervous system to cause muscle relaxation and sedation. (GtoPdb)
DESCRIPTION Inducible nitric oxide synthetase inhibitor; skeletal muscle relaxant (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
26
AdooQ Bioactive Compound Library
A16449
Cayman Chemical Bioactives
18869
25826
34237
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1371
ChEMBL Drugs
CHEMBL1371
Drug Repurposing Hub
DrugBank
DB00356
DrugBank Approved Drugs
DB00356
DrugCentral
626
DrugCentral Approved Drugs
626
DrugMAP
DMCYVDT
DrugMAP Approved Drugs
DMCYVDT
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
2322
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1371
MedChem Express Bioactive Compound Library
HY-B1462
NCATS Inxight Approved Drugs
H0DE420U8G
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
chlorzoxazone
TargetMol Bioactive Compound Library
T1650
The Spectrum Collection
External IDs
45
Properties
(calculated by RDKit )
Molecular Weight
168.99
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
2
cLogP
1.77
TPSA
46.0
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
iNOS
MOA
Unknown molecular target
bacterial 30S ribosomal subunit inhibitor
Target
Intermediate conductance calcium-activated potassium channel protein 4
Calcium-activated potassium channel subunit alpha-1
Potassium Channel
KCNMA1, KCNN4
Cytochrome P450
P450 (e.g. CYP17)
Pathway
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Indication
muscle relaxant
Therapeutic Class
Analgesics
Source data