General
Preferred name
CYCLIZINE
Synonyms
Marezine hydrochloride ()
Echnatol ()
Fortravel ()
CYCLIZINE HYDROCHLORIDE ()
Cyclizine Dihydrochloride ()
Cyclizine 2HCl ()
CYCLIZINE LACTATE ()
Ciclizina ()
NSC-26608 ()
Cyclizine hcl ()
Marzine ()
NSC-169102 ()
Marezine ()
Cyclizine (hydrochloride) ()
P&D ID
PD002402
CAS
82-92-8
303-25-3
5897-18-7
5897-19-8
Tags
available
drug
drug candidate
Approved by
FDA
Drug indication
Nausea
allergic disease
Drug Status
withdrawn
approved
Max Phase
4.0
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cyclizine is an antihistamine drug used primarily for its anti-nausea and antiemetic actions.
Cyclizine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
DESCRIPTION Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity. (BOC Sciences Bioactive Compounds)
DESCRIPTION Cyclizine is an antihistamine and antiemetic drug used for the prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness, and vertigo. (Enamine Bioactive Compounds)
DESCRIPTION Cyclizine hydrochloride (Fortravel) , sold under a number of brand names, is a medication used to treat and prevent nausea, vomiting and dizziness due to motion sickness or vertigo. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
25
BOC Sciences Bioactive Compounds
cyclizine-dihydrochloride-cas-5897-18-7-item-84-463466
Cayman Chemical Bioactives
31190
ChEMBL Approved Drugs
CHEMBL648
CHEMBL1200497
ChEMBL Drugs
CHEMBL648
CHEMBL1324714
CHEMBL1200497
Drug Repurposing Hub
DrugBank
DB01176
DrugBank Approved Drugs
DB01176
DrugCentral
749
DrugCentral Approved Drugs
749
DrugMAP
DM9G7BS
DrugMAP Approved Drugs
DM9G7BS
DrugMatrix
Enamine Bioactive Compounds
EBC-28049
Guide to Pharmacology
7151
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL648
Mcule NIBR MoA Box Subset
MCULE-5937988027
NCATS Inxight Approved Drugs
QRW9FCR9P2
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
cyclizine
cyclizine-2hcl
TargetMol Bioactive Compound Library
T4056
The Spectrum Collection
Withdrawn 2.0
1215
External IDs
78
Properties
(calculated by RDKit )
Molecular Weight
266.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.02
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
Drugs Acting on Histamine Receptors
histamine receptor modulator
Indication
nausea, vomiting, vertigo, motion sickness
Disease Area
gastroenterology, neurology/psychiatry
Target
HRH1, SULT1E1
Histamine Receptor
ATC
R06AE03
R06AE53
Therapeutic Class
Antiemetics
Source data