General
Preferred name
CYCLIZINE
Synonyms
Marezine hydrochloride ()
Echnatol ()
Fortravel ()
CYCLIZINE HYDROCHLORIDE ()
CYCLIZINE LACTATE ()
Cyclizine 2HCl ()
Cyclizine Dihydrochloride ()
NSC-26608 ()
Marezine ()
Cyclizine hcl ()
Marzine ()
NSC-169102 ()
Cyclizine (hydrochloride) ()
P&D ID
PD002402
CAS
82-92-8
303-25-3
5897-18-7
5897-19-8
Tags
natural product
drug
available
Approved by
FDA
Drug Status
approved
withdrawn
Drug indication
Antinauseant
Anti-Emetic
Anti-Emetic,Antihistaminic,Antinauseant
Nausea
Max Phase
Phase 4
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cyclizine is an antihistamine drug used primarily for its anti-nausea and antiemetic actions.
Cyclizine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
Cyclizine is on the World Health Organisation's List of Essential Medicines. Click here to access the pdf version of the WHO's 21st Essential Medicines list (2019). (GtoPdb)
DESCRIPTION
Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
24
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
74
Molecular Weight
266.18
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.02
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
virtual
MOA
Drugs Acting on Histamine Receptors
histamine receptor modulator
Indication
nausea, vomiting, vertigo, motion sickness
Disease Area
gastroenterology, neurology/psychiatry
Target
HRH1, SULT1E1
Histamine Receptor
ATC
R06AE03
R06AE53
Therapeutic Class
Antiemetics
Source data
