General
Preferred name
DACARBAZINE
Synonyms
Imidazole Carboxamide ()
DTIC-Dome, Imidazole Carboxamide,NSC-45388 ()
(E)-dacarbazine ()
Dacarbazine (NSC-45388) ()
DacarbazineDTIC-DomeDTICImidazole carboxamide4-(Dimethyltriazeno)imidazole-5-carboxamideDi-me-triazenoimidazolecarboxamideDimethyltriazenoimidazolecarboxamide(Dimethyltriazeno)imidazolecarboxamide5-(Dimethyltriazeno)imidazole-4-carboxamide5-(Dimethyltriazeno)imidazole-4-carboximide ()
Dicarbazine ()
DTIC ()
NCI C04717 ()
Biocarbazine r ()
DIC ()
Dacarbazina ()
Dacarbasine ()
NSC-45388 ()
Dacarbazinum ()
Decarbazine ()
DTIC-Dome ()
Dacarbazine-d6 ()
P&D ID
PD002396
CAS
4342-03-4
1185241-28-4
Tags
available
drug
nuisance
Approved by
FDA
First approval
1975
Drug indication
Melanoma
Metastatic melanoma
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 ¦Ìg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma[1][2][3][4][5].
DESCRIPTION DNA alkylator (Informer Set)
Cell lines
4
Organisms
0
Compound Sets
23
Axon Medchem Screening Library
3459
Cayman Chemical Bioactives
21877
30771
ChEMBL Approved Drugs
CHEMBL476
ChEMBL Drugs
CHEMBL476
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00851
DrugBank Approved Drugs
DB00851
DrugCentral
773
DrugCentral Approved Drugs
773
DrugMAP
DMNPZL4
DrugMAP Approved Drugs
DMNPZL4
Informer Set
32622
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL476
MedChem Express Bioactive Compound Library
HY-B0078
NCATS Inxight Approved Drugs
7GR28W0FJI
NIH Approved Oncology Drugs
99125
NIH Mechanistic Set
NPC Screening Collection
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
Dacarbazine
The Spectrum Collection
External IDs
35
Properties
(calculated by RDKit )
Molecular Weight
182.09
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
0.07
TPSA
99.73
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
5.0
QED
0.51
Structural alerts
2
azo_A(324)
[#7;!R]=[#7]
PAINS Family A
Genotoxic
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Compound status
FDA
Indication
melanoma, Hodgkin's lymphoma
Disease Area
oncology, hematologic malignancy
Target
PGD, POLA2
Apoptosis
Nucleoside antimetabolite/analog
Antineoplastic and Immunosuppressive Antibiotics,DNA/RNA Synthesis
MOA
DNA alkylating agent
Therapeutic Class
Anticancer Agents
Pathway
Cell Cycle/DNA Damage
Source data