General
Preferred name
DAPSONE
Synonyms
4,4¡ä-Diaminodiphenyl sulfone ()
DDS ()
Sulphadione ()
4,4??-Sulfonyldianiline ()
4-Aminophenyl sulfone ()
Bis(4-aminophenyl) sulfone ()
4,4'-Diaminodiphenylsulfone ()
Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis sulfone, ()
4,4¡ä-Sulfonyldianiline ()
4,4??Diaminodiphenyl sulfone ()
4,4¡®-Sulfonyldianiline ()
Dapsone, 4,4??Diaminodiphenyl sulfone, 4,4??Sulfonyldianiline, 4-Aminophenyl sulfone, Bis sulfone, ()
Dapson ()
4,4′-Diaminodiphenyl sulfone ()
Dapsone, 4,4¡ä-Diaminodiphenyl sulfone, 4,4¡ä-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS ()
Dapsonum ()
NSC-6091 ()
Novophone ()
J04BA02 ()
Aczone ()
Diaphenylsulfone ()
NSC-6091D ()
Servidapson ()
Diaminodiphenylsulfone ()
Dapsone-d8 ()
P&D ID
PD002394
CAS
80-08-0
557794-38-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1979
Drug Status
investigational
approved
Drug indication
Suppressant (dermatitis herpetiformis)
Pneumocystis pneumonia
Antibacterial (leprostatic)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dapsone is a sulfonamide-related antibacterial, antimalarial and anti-inflammatory drug. In bacteria it inhibits dihydropteroate synthase-mediated production of folic acid, which has the effect of disrupting the availability of thymidylate for DNA synthesis.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
25
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
248.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.68
TPSA
86.18
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Microbiology&virology
Anti-infection
Immunology/Inflammation
Metabolic Enzyme/Protease
NF-κB
Target
antibiotic
DHFR
Bacterial
Parasite
Reactive Oxygen Species
Antibiotics
Indication
dermatitis herpetiformis (DH), leprosy
Disease Area
dermatology, infectious disease
MOA
bacterial antifolate
Therapeutic Class
Antiinflammatory Agents
Source data
