General
Preferred name
DAPSONE
Synonyms
4,4¡ä-Diaminodiphenyl sulfone ()
DDS ()
4,4'-Sulfonyldianiline ()
Bis(4-aminophenyl) sulfone ()
Sulphadione ()
4,4'-Diaminodiphenylsulfone ()
4-Aminophenyl sulfone ()
Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis sulfone, ()
4,4¡ä-Sulfonyldianiline ()
4,4??Diaminodiphenyl sulfone ()
4,4¡®-Sulfonyldianiline ()
Dapsone, 4,4??Diaminodiphenyl sulfone, 4,4??Sulfonyldianiline, 4-Aminophenyl sulfone, Bis sulfone, ()
Dapson ()
4,4′-Diaminodiphenyl sulfone ()
Dapsone, 4,4¡ä-Diaminodiphenyl sulfone, 4,4¡ä-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS ()
Dapsone-d8 ()
Novophone ()
Dapsona ()
J04BA02 ()
Dapsonum ()
Diaphenylsulfone ()
NSC-6091 ()
NSC-6091D ()
Servidapson ()
Aczone ()
Diaminodiphenylsulfone ()
P&D ID
PD002394
CAS
80-08-0
557794-38-4
Tags
available
drug
Approved by
FDA
First approval
1979
Drug indication
acne
Pneumocystis pneumonia
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Dapsone is a sulfonamide-related antibacterial, antimalarial and anti-inflammatory drug. In bacteria it inhibits dihydropteroate synthase-mediated production of folic acid, which has the effect of disrupting the availability of thymidylate for DNA synthesis.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
Dapsone (4,4¡ä-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities[1]. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al[2][3].
PRICE
29
DESCRIPTION
Dapsone is a sulfone drug. It has anti-inflammatory, antimalarial, and antibacterial activity. It inhibits Dihydrofolate reductase (gene DHFR) and Dihydropteroate synthase. Dapsone is used for the treatment and management of leprosy and dermatitis herpetiformis.
(Enamine Bioactive Compounds)
DESCRIPTION
Dapsone (Sulphadione) has activity against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
26
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
53
Molecular Weight
248.06
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
1.68
TPSA
86.18
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Immunology/Inflammation
Metabolism
Microbiology/virology
NF-κB
Anti-infection
Metabolic Enzyme/Protease
Target
antibiotic
Bacterial
Parasite
Reactive Oxygen Species
DHFR
Reactive Oxygen Species (ROS)
Antibiotics
Indication
dermatitis herpetiformis (DH), leprosy
Disease Area
dermatology, infectious disease
MOA
bacterial antifolate
Therapeutic Class
Antiinflammatory Agents
Source data
