General
Preferred name
DESIPRAMINE HYDROCHLORIDE
Synonyms
NSC-114901 ()
Desmethylimipramine ()
JB-8181 ()
EX-4355 ()
Norimipramine ()
G-35020 ()
Desipramine (HCl) ()
Desipramine (hydrochloride) ()
Desmethylimipramine, Norimipramine, EX-4355, G-35020, JB-8181, NSC-114901 ()
Pertofran ()
EX 4355 ()
Desipramine hcl ()
Norpramin ()
Pertofrane ()
RMI-9384A ()
RMI 9,384A ()
DMI ()
18-8181 ()
Desipramine hydrochloride ()
Desipramine (hydrochloride) (CRM) ()
P&D ID
PD002389
CAS
58-28-6
50-47-5
Tags
available
drug
nuisance
Drug Status
approved
Max Phase
4.0
Drug indication
small cell lung carcinoma
First approval
1964
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
PRICE 29
DESCRIPTION Desipramine is a tricyclic antidepressant that selectively blocks reuptake of norepinephrine from the neuronal synapse. It also inhibits serotonin reuptake, but to a lesser extent compared to tertiary amine TCAs such as imipramine. (Enamine Bioactive Compounds)
DESCRIPTION Antidepressant (LOPAC library)
DESCRIPTION Desipramine hydrochloride (Norimipramine) ,a secondary amine tricyclic antidepressant (TCA), is the hydrochloride salt form of desipramine. In the central nervous system (CNS), Desipramine hydrochloride blocks the re-uptake of neurotransmitters, including norepinephrine and serotonin. This leads to an increase in the amount of these neurotransmitters in the synaptic cleft and prolongs their activities postsynaptically. (TargetMol Bioactive Compound Library)
DESCRIPTION Superoxide scavenger; antioxidant (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
16
Cayman Chemical Bioactives
19105
15304
ChEMBL Approved Drugs
CHEMBL1696
ChEMBL Drugs
CHEMBL1696
CZ-OPENSCREEN Bioactive Library
Enamine Bioactive Compounds
EBC-28045
EU-OPENSCREEN Bioactive Compound Library
EOS100774
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1696
MedChem Express Bioactive Compound Library
HY-B1272
NIH Clinical Collections (NCC)
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
desipramine-hydrochloride
TargetMol Bioactive Compound Library
T0991
The Spectrum Collection
Tocris Bioactive Compound Library
3067
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
302.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.95
TPSA
15.27
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
7.0
QED
0.86
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Uptake
Target
5-HT
Adrenergic Receptor
Dopamine Transporter
Serotonin Transporter
5-HT Receptor,Serotonin Transporter
Primary Target
Adrenergic Transporters
MOA
Inhibitor
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Source data