General
Preferred name
DIENESTROL
Synonyms
Restrol ()
Dehydrostilbestrol ()
Dienoestrol ()
Cycladiene ()
Dienestrol ()
Synestrol ()
Hormofemin ()
Oestrasid ()
Follidiene ()
Dienestrol diacetate, .alpha.- ()
Dv ()
Gynefollin ()
Oestrodiene ()
Dienol ()
NSC-59809 ()
Estraguard ()
Dinovex ()
Dienestrol trans-form ()
.alpha.-dienestrol diacetate ()
Dienestrol, .alpha.- ()
Estragard ()
Oestroral ()
Retalon ()
Estroral ()
P&D ID
PD002378
CAS
84-17-3
13029-44-2
Tags
available
drug
Approved by
FDA
First approval
1947
Drug indication
Atrophic vaginitis
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).; ;
MOA Dienestrol is a synthetic, non-steroidal estrogen. Estrogens passively diffuse into target cells of responsive tissues, complex with the estrogen receptors, and enter the cell's nucleus to initiate or enhance gene transcription of protein synthesis after binding to DNA.
INDICATION For use in the treatment of atrophic vaginitis and kraurosis vulvae.
TOXICITY Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
METABOLISM Hepatic.
ABSORPTION Systemic absorption and mode of action of dienestrol are undetermined.Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
DESCRIPTION Dienestrol is a synthetic, non-steroidal estrogen of the stilbestrol group. It is a close analogue of . (GtoPdb)
DESCRIPTION Dienestrol is a synthetic, non-steroidal estrogen, is an estrogen receptor agonist, for the treatment of menopausal and postmenopausal symptoms.
PRICE 29
DESCRIPTION Dienestrol is a synthetic and non-steroidal estrogen, which structurally related to stilbestrol. It is an estrogen receptor agonist and a metabolite of Diethylstilbestrol. It is used in the treatment of menopausal and postmenopausal symptoms. (BOC Sciences Bioactive Compounds)
DESCRIPTION Dienestrol (Restrol) is a synthetic and nonsteroidal estrogen, which is an estrogen receptor agonist. Estrogens can increase a normal clear discharge from the vagina and make the vulva and urethra healthy. (TargetMol Bioactive Compound Library)
Compound Sets
19
BOC Sciences Bioactive Compounds
dienestrol-cas-84-17-3-348293
ChEMBL Approved Drugs
CHEMBL1018
ChEMBL Drugs
CHEMBL1018
Drug Repurposing Hub
DrugBank
DB00890
DrugBank Approved Drugs
DB00890
DrugCentral
870
DrugCentral Approved Drugs
870
DrugMAP
DMBSXI0
DrugMAP Approved Drugs
DMBSXI0
Guide to Pharmacology
7160
MedChem Express Bioactive Compound Library
HY-B1403
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Dienestrol(Restrol)
TargetMol Bioactive Compound Library
T0035
The Spectrum Collection
Withdrawn 2.0
49
External IDs
33
Properties
(calculated by RDKit )
Molecular Weight
266.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
2
Aromatic Ring Count
2
cLogP
4.6
TPSA
40.46
Fraction CSP3
0.11
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ER
Estrogen Receptor/ERR
ESR1
Estrogen/progestogen Receptor
Indication
menopause
MOA
Estrogen receptor agonist
ATC
G03CB01
G03CC02
Therapeutic Class
Estrogens
Pathway
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Solubility
10 mM in DMSO
Source data