General
Preferred name
DIETHYLSTILBESTROL
Synonyms
Stilbestrol ()
DES ()
(E)-diethylstilbestrol ()
Dietilestilbestrol ()
Stilbetin ()
Stilboesterol ()
Stilbestro ()
Distilbene ()
NSC-3070 ()
Apstil ()
Tampovagan ()
APSTIL ()
DIETILESTILBESTROL ()
DISTILBENE ()
STILBESTRO ()
STILBETIN ()
TAMPOVAGAN ()
P&D ID
PD002375
CAS
56-53-1
22610-99-7
Tags
available
drug
Approved by
FDA
First approval
1973
Drug indication
Gonorrheal vaginitis
Neoplasm
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Nonsteroidal estrogen receptor alpha (ERα) agonist. (GtoPdb)
DESCRIPTION Diethylstilbestrol is a non-steroidal female hormone that has oral activity and can act on menopausal and postmenopausal disorders. Diethylstilbestrol can induce DNA oxidation and Apoptosis of spermatogonial stem cells. Diethylstilbestrol can induce thymocyte Autophagy Diethylstilbestrol is a 11¦Â-hydroxysteroid dehydrogenase 2 (HSD11B2) inhibitor.[1][2][3][4][5][6][7][8].
PRICE 29
DESCRIPTION Diethylstilbestrol is a synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders, and in the treatment of prostate cancer. (Enamine Bioactive Compounds)
DESCRIPTION Diethylstilbestrol (DES) is used in the treatment of menopausal and postmenopausal disorders. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
1
Compound Sets
28
Axon Medchem Screening Library
3320
Cayman Chemical Bioactives
10006876
ChEMBL Approved Drugs
CHEMBL411
ChEMBL Drugs
CHEMBL411
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00255
DrugBank Approved Drugs
DB00255
DrugCentral
875
DrugCentral Approved Drugs
875
DrugMAP
DMN3UXQ
DrugMAP Approved Drugs
DMN3UXQ
Enamine Bioactive Compounds
EBC-11048
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101575
EUbOPEN Chemogenomics Library
EUB0002144
Guide to Pharmacology
2801
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL411
MedChem Express Bioactive Compound Library
HY-14598
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
NURSA ligand set
nursa/index.jsf?doi=10.1621%2FGYGXGQW5SL
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Diethylstilbestrol(Stilbestrol)
TargetMol Bioactive Compound Library
T1216
The Spectrum Collection
Withdrawn 2.0
w119
External IDs
40
Properties
(calculated by RDKit )
Molecular Weight
268.15
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.83
TPSA
40.46
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.78
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ER
Estrogen Receptor/ERR
ESR1, ESR2, ESRRB, ESRRG
ER-a agonist
Apoptosis
Autophagy
Estrogen/progestogen Receptor
Member status
member
MOA
Chloride Channel Blockers
Estrogen Receptor (ER) Agonists
Estrogen receptor agonist
ATC
G03CB02
L02AA01
Toxicity type
reproductive
Therapeutic Class
Anticancer Agents
Pathway
Vitamin D Related/Nuclear Receptor
Endocrinology/Hormones
Recommended Cell Concentration
None
Source data