General
Preferred name
DIPHENHYDRAMINE HYDROCHLORIDE
Synonyms
DPH ()
Diphenhydramine hcl ()
Diphenhydramine Hydrochloride ()
Diphenhydramine (hydrochloride) ()
Benylin ()
Dibenil ()
Benadryl Preservative Free ()
Fedril ()
Hydramine ()
Gppe Cough Expect Paed ()
Paxidorm ()
Sleepia ()
Belix ()
Medinex ()
Vicks Formula 44 ()
Diphen ()
Dreemon ()
Silphen ()
Caladryl ()
Diphenhydramine Hydrochloride Preservative Free ()
Beldin ()
NSC-33299 ()
Dimedrol ()
Nytol One-A-Night ()
Histergan ()
Nightcalm ()
Tixylix Catarrh ()
Coltex ()
Benadryl ()
Gppe Oral Soln ()
Nytol ()
P&D ID
PD002365
CAS
147-24-0
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Antihistaminic
Antitussive
First approval
1946
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION H1 Histamine receptor antagonist (LOPAC library)
DESCRIPTION Muscarinic receptor agonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
14
AdooQ Bioactive Compound Library
A10318
Cayman Chemical Bioactives
22489
11158
ChEMBL Approved Drugs
CHEMBL1620
ChEMBL Drugs
CHEMBL1620
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101347
LOPAC library
MedChem Express Bioactive Compound Library
HY-B0303A
NIH Clinical Collections (NCC)
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
Diphenhydramine-hydrochloride(Benadryl)
TargetMol Bioactive Compound Library
T0330
The Spectrum Collection
Tocris Bioactive Compound Library
3072
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
291.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
3.78
TPSA
12.47
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.8
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Anti-infection
Apoptosis
Metabolic Enzyme/Protease
Neuronal Signaling
Target
H1 receptor
Bacterial
Endogenous Metabolite
Histamine Receptor
Primary Target
Histamine H1 Receptors
MOA
Antagonist
Source data