General
Preferred name
DIPYRIDAMOLE
Synonyms
Dipyridamolum ()
NSC-515776 ()
Persantin ()
Dipyridamol ()
Dipyudamine ()
Dypyridamole ()
Dipyridamole (NSC 515776) ()
Persantine,NSC-515776 ()
Ofcram pr ()
B01AC07 ()
Cerebrovase 25 ()
Modaplate ()
Persantine ()
Persantin ret ()
Cerebrovase 100 ()
Iv persantine ()
Pyridantin ()
RA-8 ()
Attia ()
Vasyrol ()
Dipyridamole-d16 ()
P&D ID
PD002363
CAS
58-32-2
2712261-50-0
Tags
obsolete probe
probe
natural product
drug
available
Approved by
FDA
First approval
1961
Drug Status
approved
Drug indication
Vasodilator (coronary)
Hypertension
Max Phase
Phase 4
Probe info
Probe selectivity
protein-selective
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dipyridamole is a phosphodiesterase (PDE) inhibitor. (GtoPdb)
DESCRIPTION Potent, selective I2 ligand. Putative antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Adenosine transport inhibitor (Tocriscreen Plus)
DESCRIPTION Coronary vasodilator; adenosine transport inhibitor (LOPAC library)
DESCRIPTION Adenosine transport inhibitor (Tocriscreen Total)
Cell lines
1
Organisms
6
Compound Sets
38
AdooQ Bioactive Compound Library
A10319
Cayman Chemical Bioactives
18189
30138
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL932
ChEMBL Drugs
CHEMBL932
Concise Guide to Pharmacology 2017/18
4807
Concise Guide to Pharmacology 2019/20
4807
Concise Guide to Pharmacology 2021/22
4807
Concise Guide to Pharmacology 2023/24
4807
Drug Repurposing Hub
DrugBank
DB00975
DrugBank Approved Drugs
DB00975
DrugCentral
924
DrugCentral Approved Drugs
924
DrugMAP
DMXY30O
DrugMAP Approved Drugs
DMXY30O
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
4807
Ki Database
Dipyridamole
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL932
MedChem Express Bioactive Compound Library
HY-B0312
NCATS Inxight Approved Drugs
64ALC7F90C
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Obsolete Compounds
dipyridamole
Prestwick Chemical Library
Probe Miner (suitable probes)
Q99808/681918
ReFrame library
Selleckchem Bioactive Compound Library
Dipyridamole(Permole,-Persantine)
TargetMol Bioactive Compound Library
T1618
The Spectrum Collection
Tocris Bioactive Compound Library
0691
Tocriscreen Plus
0691
Tocriscreen Total
ZINC Tool Compounds
ZINC000000643046
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
504.32
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
4
Rotatable Bonds
12
Ring Count
4
Aromatic Ring Count
2
cLogP
-0.02
TPSA
145.44
Fraction CSP3
0.75
Chiral centers
0.0
Largest ring
6.0
QED
0.31
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
3',5'-cyclic phosphodiesterase
Equilibrative nucleoside transporter 1
Sodium/nucleoside cotransporter 1
Adenosine Deaminase
PDE
ADA, PDE10A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, SLC29A1
Phosphodiesterase (PDE)
Target Type
Transporters
MOA
phosphodiesterase inhibitor
Inhibitor
Adenosine Transporter Inhibitor
Phosphodiesterase III Inhibitors
Phosphodiesterase V (PDE5A) Inhibitors
Pathway
Metabolism
Apoptosis
Metabolic Enzyme/Protease
Primary Target
Nucleoside Transporters
Member status
member
Indication
coronary artery disease (CAD), peripheral artery disease (PAD), hypertension
Therapeutic Class
Vasodilator Agents
Source data