General
Preferred name
DISULFIRAM
Synonyms
Tetraethylthiuram disulfide ()
TETD ()
NSC 190940 ()
TETRAETHYLTHIURAM DISULFIDE97-77-8 ()
Disulfiram (NSC 190940) ()
NSC 190940, Tetraethylthiuram disulfide, TETD ()
ORA102 ()
NSC-25953 ()
Esperal ()
ORA-102 ()
Antabuse ()
Disulfiram-d20 ()
P&D ID
PD002360
CAS
97-77-8
11078-22-1
1216403-88-1
Tags
covalent binder
nuisance
natural product
drug
available
Approved by
FDA
First approval
1951
Drug Status
approved
Drug indication
Alcohol dependence
Severe acute respiratory syndrome (SARS)
Alcoholism
Coronavirus Disease 2019 (COVID-19)
Alcohol Deterrent
Middle East Respiratory Syndrome (MERS)
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Disulfiram inhibits acetaldehyde dehydrogenase to expedite acetaldehyde accumulation and rapid onset (within 5-10 minutes of alcohol intake) of the unpleasant effects typical of a hangover.
(GtoPdb)
DESCRIPTION
TrkB agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Alcohol dehydrogenase inhibitor
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
5
Organisms
2
Compound Sets
31
AdooQ Bioactive Compound Library
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
CovalentInDB
CovBinderInPDB
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
LINCS compound set
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
296.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
3.62
TPSA
6.48
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.57
Structural alerts
3
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Nonspecific reactivity
Nuisance compounds in cellular assays
Custom attributes
(extracted from source data)
Selectivity
Alcohol Dehydrogenase
MOA
aldehyde dehydrogenase inhibitor
Activator
aldehyde dehydrogenase inhibitor, DNA methyltransferase inhibitor, TRPV agonist
Target
Aldehyde dehydrogenase
ALDH1
DBH
ALDH2, DBH
Aldehyde dehydrogenase (ALDH)
Interleukin Related
Pyroptosis
Apoptosis related,COVID-19,Dehydrogenase,Pyroptosis
Pathway
Metabolism
Apoptosis
Immunology/Inflammation
Metabolic Enzyme/Protease
Primary Target
Ca2+-ATPase
Indication
abstinence from alcohol
Therapeutic Class
Alcohol Deterrents
Antiviral Agents
Source data