General
Preferred name
DISULFIRAM
Synonyms
Tetraethylthiuram disulfide ()
TETD ()
NSC 190940 ()
TETRAETHYLTHIURAM DISULFIDE97-77-8 ()
Disulfiram (NSC 190940) ()
NSC 190940, Tetraethylthiuram disulfide, TETD ()
ORA102 ()
Disulfirame ()
ORA-102 ()
NSC-25953 ()
Antabuse ()
Esperal ()
Disulfiram-d20 ()
P&D ID
PD002360
CAS
97-77-8
11078-22-1
1216403-88-1
Tags
available
nuisance
drug
covalent binder
Approved by
FDA
First approval
1951
Drug indication
Middle East Respiratory Syndrome (MERS)
Coronavirus Disease 2019 (COVID-19)
Severe acute respiratory syndrome (SARS)
Alcohol Deterrent
Alcohol dependence
Alcoholism
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Disulfiram inhibits acetaldehyde dehydrogenase to expedite acetaldehyde accumulation and rapid onset (within 5-10 minutes of alcohol intake) of the unpleasant effects typical of a hangover. (GtoPdb)
DESCRIPTION TrkB agonist (Tocris Bioactive Compound Library)
DESCRIPTION Alcohol dehydrogenase inhibitor (LOPAC library)
Cell lines
7
Organisms
2
Compound Sets
32
AdooQ Bioactive Compound Library
A10320
Cayman Chemical Bioactives
15303
28536
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL964
ChEMBL Drugs
CHEMBL964
CovalentInDB
CI002169
CovBinderInPDB
CBR002114
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00822
DrugBank Approved Drugs
DB00822
DrugCentral
928
DrugCentral Approved Drugs
928
DrugMAP
DMBMKV8
DMCL2OK
DrugMAP Approved Drugs
DMCL2OK
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7168
LINCS compound set
10507-999
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL964
MedChem Express Bioactive Compound Library
HY-B0240
NCATS Inxight Approved Drugs
TR3MLJ1UAI
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Disulfiram(Antabuse)
TargetMol Bioactive Compound Library
T0054
The Spectrum Collection
Tocris Bioactive Compound Library
3807
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
296.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
3.62
TPSA
6.48
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.57
Structural alerts
3
aggregator (ZINC)
Aggregators
aggregator (Aggregator Advisor)
Aggregators
Nonspecific reactivity
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Alcohol Dehydrogenase
MOA
aldehyde dehydrogenase inhibitor
Activator
aldehyde dehydrogenase inhibitor, DNA methyltransferase inhibitor, TRPV agonist
Target
Aldehyde dehydrogenase
ALDH1
DBH
ALDH2, DBH
Aldehyde dehydrogenase (ALDH)
Cuproptosis
Interleukin Related
Pyroptosis
Apoptosis related,COVID-19,Dehydrogenase,Pyroptosis
Pathway
Metabolism
Apoptosis
Immunology/Inflammation
Metabolic Enzyme/Protease
Primary Target
Ca2+-ATPase
Indication
abstinence from alcohol
Therapeutic Class
Alcohol Deterrents
Antiviral Agents
Source data