General
Preferred name
HEXACHLOROPHENE
Synonyms
Phenol, 2,2'-methylenebis(3,4,6-trichloro)- ()
Hexachlorofen ()
Fostril ()
Nabac ()
HEXACHLOROPHENE DISODIUM ()
Gamophen ()
Septisol ()
Soy-Dome ()
Turgex ()
pHisoHex ()
Pre-Op ()
E-Z Scrub ()
Septi-Soft ()
Hexa-Germ ()
Phiso-Scrub ()
Scrubteam Surgical Spongebrush ()
Hexascrub ()
Germa-Medica "Mg" ()
Germa-Medica ()
"germa-medica ""mg""" ()
Pre-Op ii ()
P&D ID
PD002310
CAS
70-30-4
139411-96-4
3247-34-5
Tags
natural product
drug
available
Approved by
FDA
First approval
1949
Drug Status
approved
withdrawn
Drug indication
Detergent
Anti-Infective, Topical
Bacterial infection
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Hexachlorophene is used as a topical anti-infective, antibacterial agent, and as a soil fungicide, plant bactericide. It exhibits bacteriostatic action against Gram-positive organisms, but is much less effective against Gram-negative organisms. Reported to inhibit N-Acyl-phosphatidylethanolamine phospholipase D (NAPE-PLD) activity .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
5
Compound Sets
25
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
LSP-OptimalKinase library (Laboratory of Systems Pharmacology)
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
49
Molecular Weight
403.85
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
2
Aromatic Ring Count
2
cLogP
6.61
TPSA
40.46
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.55
Structural alerts
2
aggregator (Aggregator Advisor)
Aggregators
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
GLUD1, SDHD
Pathway
Anti-infection
Member status
member
MOA
Large Conductance K(Ca) 1.1 (BK, maxi K+) Channel Activators
Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2
Autotaxin) Inhibitors
Potassium Channel activator
Indication
gram-positive bacterial infections
ATC
D08AE01
Toxicity type
neurological
Therapeutic Class
Antiinfective Agents
Source data
