General
Preferred name
HEXYLRESORCINOL
Synonyms
Acrisorcinum ()
4-Hexylresorcinol ()
4-hexyl resorcinol ()
E-586 ()
INS-586 ()
Sucrets ()
INS NO.586 ()
P&D ID
PD002309
CAS
136-77-6
Tags
available
drug
Approved by
FDA
Drug indication
Discovery agent
Drug Status
approved
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
Hexylresorcinol is predominantly employed as the active ingredient in lotions, sprays, or lozenges indicated as a (a) topical antiseptic to help prevent skin infection in minor cuts, scrapes, or burns, or (b) as an antiseptic and local anesthetic for the relief of a sore throat and its associated pain [L2734, L2735].; ; In addition, hexylresorcinol is used as an active ingredient in various commercial cosmetic skincare products as an anti-aging cream [L2736] while other studies have looked into whether or not the compound could be used effectively as an anti-inflammatory agent or even as an anti-cancer therapy [L2736].
TOXICITY
In the over-the-counter antiseptic and oral analgesic sprays and lozenges that hexylresorcinol is typically employed as the active ingredient, it is noted that overdosage of the agent may cause minor gastrointestinal irritation [L2735, F57, F58]. ; ; The probable oral LD50 of hexylresorcinol in humans has been estimated to be between 500 and 5000 mg/kg body weight, between 1 oz and 1 pint (or 1 lbs) for a 70 kg person [L2739, L2740].
DESCRIPTION
Hexylresorcinol (4-Hexylresorcinol) is a natural compound found in plants with antimicrobial, anthelmintic, antiseptic and antitumor activities. Hexylresorcinol can induce apoptosis in squamous carcinoma cells. Hexylresorcinol is a reversible and noncompetitive inhibitor of ¦Á-glucosidase. Hexylresorcinol has protective effects against oxidative DNA damage[1][2][3][4][5].
PRICE
29
DESCRIPTION
4-Hexylresorcinol, a phenol derivative, could be commonly used as antioxidant, vermifuge and food additives.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Hexylresorcinol is a substituted dihydroxybenzene. It exhibits antiseptic, anthelmintic, and local anesthetic properties. Hexylresorcinol is predominantly employed as the active ingredient in lotions, sprays, or lozenges indicated as a topical antiseptic to help prevent skin infection in minor cuts, scrapes, or burns, or as an antiseptic and local anesthetic for the relief of a sore throat and its associated pain.
(Enamine Bioactive Compounds)
DESCRIPTION
Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene utilized topically as an antiseptic for minor skin infection treatment.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
1
Compound Sets
20
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Enamine Bioactive Compounds
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
194.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
1
Aromatic Ring Count
1
cLogP
3.22
TPSA
40.46
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Bacterial
diphenolase
monophenolase
Parasite
TYR
Endogenous Metabolite
Glycosidase
Tyrosinase
Indication
skin infections, first-aid antiseptic
MOA
local anesthetic
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Solubility
DMSO : ≥ 1.8 mg/mL
Source data
