General
Preferred name
HYDRALAZINE HYDROCHLORIDE
Synonyms
Hydralazine HCl ()
Apresoline ()
HYDRALAZINE ()
Hydralazine (hydrochloride) ()
NSC-89394 ()
Hydralazini hydrochloridum ()
MC-1101 ()
Dralzine ()
Apressinum ()
P&D ID
PD002305
CAS
86-54-4
304-20-1
Tags
natural product
drug
available
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antihypertensive
First approval
1953
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Non-selective MAO-A/B inhibitor; antihypertensive (LOPAC library)
Compound Sets
12
AdooQ Bioactive Compound Library
A10455
Cayman Chemical Bioactives
23121
ChEMBL Approved Drugs
CHEMBL542541
ChEMBL Drugs
CHEMBL542541
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100745
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL542541
MedChem Express Bioactive Compound Library
HY-B0464
Selleckchem Bioactive Compound Library
Hydralazine-hydrochloride
TargetMol Bioactive Compound Library
T1613
The Spectrum Collection
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
196.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
2
cLogP
1.34
TPSA
63.83
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.53
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
MAO-A/B
Pathway
Metabolism
Neuroscience
Apoptosis
Target
MAO
AO
Bcl-2 Family
Caspase
Potassium Channel
MOA
MAO inhibitor
Source data