General
Preferred name
HYDROCHLOROTHIAZIDE
Synonyms
HYDROCHLORTHIAZIDE ()
Diovan HCT-hydrochlorothiazide ()
HCTZ ()
Hydrochlorothiazide ()
Hydrochlorothiazide component of unipres ()
Copalia-hct ()
Hydrochlorothiazide component of aldoril ()
Hydrochlorothiazide component of rasitrio ()
Hydrochlorothiazide component of moduretic ()
Hydrochlorothiazide component of vaseretic ()
Hidrotiazida ()
Hydrosaluric ()
Hydrochlorothiazide component of lotensin hct ()
Dihydrochlorurite ()
Hydrochlorothiazide component of pritorplus ()
Hydrochlorothiazide component of hydroserpine plus (r-h-h) ()
Hydrochlorothiazide component of maxzide ()
Hydrochlorothiazide component of monopril hct ()
Chlorosulthiadil ()
Hydrodiuril ()
Hydrochlorothiazide component of quinaretic ()
Hydrochlorothiazide component of diovan hct ()
Esidrex ()
Carozide ()
Hydrochlorothiazide component of accuretic ()
Hydrochlorothiaizide ()
Hydrochlorothiazide component of ifirmacombi ()
Idrotiazide ()
Apresazide ()
Hydrochlorothiazide component of amturnide ()
Hydrochlorothiazide component of irbesartan/ teva ()
Dafiro-hct ()
Esidrix ()
Hydrochlorothiazide component of aldactazide ()
Hydrochlorothiazide component of tolucombi ()
Hydrochlorothiazide component of h.r.-50 ()
Hydrochlorothiazide component of hydropres ()
Hydrochlorothiazide component of uniretic ()
Hydrochlorothiazide component of riprazo ()
Hydrochlorothiazide component of hydro-reserp ()
Vetidrex ()
Hydrochlorothiazide component of hyzaar ()
Hydrochlorothiazide component of hydro-ride ()
Hydrochlorothiazide component of lopressor hct ()
Hydrochlorothiazide component of kervezide ()
Hydrochlorothiazide component of teveten hct ()
Hydrochlorothiazide component of micardis hct ()
Hydrochlorothiazide component of serpasil-esidrix ()
Hydrochlorothiazide component of viskazide ()
Hydro-D ()
Hydrochlorothiazide component of hydra-zide ()
Hydrochlorothiazide component of tekturna hct ()
Hydrochlorothiazide component of cam-ap-es ()
Servithiazid ()
Hydrochlorothiazide component of zestoretic ()
Newtolide ()
Hydrochlorothiazide component of benicar hct ()
Lotensin hct ()
Hydrochlorothiazide component of kinzalkomb ()
Imprida-hct ()
Zide ()
Hydrochlorothiazide component of apresazide ()
Hydrochlorothiazide component of ziac ()
Hydrochlorothiazide component of dutoprol ()
Hydrochlorothiazide component of polycap ()
Hydrochlorothiazide component of esimil ()
Hydrochlorothiazide component of irbesartan/-bms ()
Hydrochlorothiazide component of tribenzor ()
SU-5879 ()
Hydrochlorothiazide Intensol ()
Hydrochlorothiazide component of prinzide ()
Oretic ()
Hydrochlorothiazide component of oreticyl forte ()
Hydrochlorothiazide component of avalide ()
Unipres ()
Hydrochlorothiazide component of apresoline-esidrix ()
Apo-Hydro ()
Hydrochlorothiazide component of dyazide ()
Microzide ()
Exforge-hct ()
Hydrochlorothiazide component of ibersartan/ zentiva ()
Hydrochlorothiazide component of ser-a-gen ()
Pantemon ()
Hydrochlorothiazide component of ser-ap-es ()
Hydrochlorothiazidum ()
Megadiuril ()
Rasilez-hct ()
Hydrochlorothiazide component of sprimeo-hct ()
Hydrochlorothiazide component of normozide ()
Hydrochlorothiazide component of micardisplus ()
Hydrochlorothiazide component of hydrap-es ()
Hidroclorotiazida ()
Ziac ()
Hydrochlorothiazide component of exforge hct ()
Hydrochlorothiazide component of hydralazine hydrochloride--reserpine ()
NSC-53477 ()
Hydrochlorothiazide-3,3-d2 ()
P&D ID
PD002304
CAS
58-93-5
125727-50-6
1219798-89-6
Tags
available
drug
Approved by
FDA
First approval
1959
Drug indication
Hypertension
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Hydrochlorothiazide is the prototypical thiazide diuretic drug. (GtoPdb)
PRICE 29
DESCRIPTION Hydrochlorothiazide (HCTZ) is a Thiazide Diuretic. The physiologic effect of hydrochlorothiazide is by means of Increased Diuresis.
DESCRIPTION Carbonic anhydrase inhibitor; diuretic (LOPAC library)
DESCRIPTION Hydrochlorothiazide is a thiazide diuretic used to treat edema associated with a number of conditions, and hypertension. Hydrochlorothiazide acts on the proximal region of the distal convoluted tubule, inhibiting reabsorption by the sodium-chloride symporter. (Enamine Bioactive Compounds)
Cell lines
0
Organisms
2
Compound Sets
33
AdooQ Bioactive Compound Library
A10456
Cayman Chemical Bioactives
21304
22671
39983
ChEMBL Approved Drugs
CHEMBL435
ChEMBL Drugs
CHEMBL435
Concise Guide to Pharmacology 2017/18
4836
Concise Guide to Pharmacology 2019/20
4836
Concise Guide to Pharmacology 2021/22
4836
Concise Guide to Pharmacology 2023/24
4836
Drug Repurposing Hub
DrugBank
DB00999
DrugBank Approved Drugs
DB00999
DrugCentral
1385
DrugCentral Approved Drugs
1385
DrugMAP
DMUSZHD
DrugMAP Approved Drugs
DMUSZHD
DrugMatrix
Enamine Bioactive Compounds
EBC-13865
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101868
Guide to Pharmacology
4836
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL435
Mcule NIBR MoA Box Subset
MCULE-6585933943
MedChem Express Bioactive Compound Library
HY-B0252
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
0J48LPH2TH
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Withdrawn 2.0
w193
External IDs
56
Properties
(calculated by RDKit )
Molecular Weight
296.96
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.35
TPSA
118.36
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Carbonic anhydrase
Member status
member
MOA
SLC12A3 gene inhibitor
thiazide diuretic
Indication
hypertension, congestive heart failure
Target
CA1, CA12, CA2, CA4, CA9, KCNMA1, SLC12A3
Potassium Channel
TGF-beta/Smad
ATC
C03AA03
Toxicity type
cardiovascular
Therapeutic Indication
Antihypertensive
Therapeutic Class
Cardiovascular
Diuretics
Pathway
Membrane Transporter/Ion Channel
Stem Cell/Wnt
Source data