General
Preferred name
HYDROCHLOROTHIAZIDE
Synonyms
HCTZ ()
HYDROCHLORTHIAZIDE ()
Diovan HCT-hydrochlorothiazide ()
Lotensin hct ()
Vetidrex ()
Unipres ()
Apo-Hydro ()
Idrotiazide ()
Dafiro-hct ()
Chlorosulthiadil ()
Hydrodiuril ()
Oretic ()
Zide ()
Imprida-hct ()
Hydro-D ()
Hydrochlorothiaizide ()
NSC-53477 ()
Microzide ()
Pantemon ()
Servithiazid ()
Apresazide ()
Hydrosaluric ()
Carozide ()
Dihydrochlorurite ()
Exforge-hct ()
Hydrochlorothiazidum ()
Rasilez-hct ()
Hidrotiazida ()
Copalia-hct ()
Hydrochlorothiazide Intensol ()
Newtolide ()
Esidrex ()
Megadiuril ()
SU-5879 ()
Esidrix ()
Hydrochlorothiazide ()
P&D ID
PD002304
CAS
58-93-5
125727-50-6
Tags
natural product
drug
available
Approved by
FDA
First approval
1959
Drug Status
withdrawn
approved
vet_approved
Drug indication
Diuretic
Hypertension
Max Phase
Phase 4
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Hydrochlorothiazide is the prototypical thiazide diuretic drug. (GtoPdb)
DESCRIPTION Carbonic anhydrase inhibitor; diuretic (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
33
AdooQ Bioactive Compound Library
A10456
Cayman Chemical Bioactives
21304
22671
ChEMBL Approved Drugs
CHEMBL435
ChEMBL Drugs
CHEMBL435
Concise Guide to Pharmacology 2017/18
4836
Concise Guide to Pharmacology 2019/20
4836
Concise Guide to Pharmacology 2021/22
4836
Concise Guide to Pharmacology 2023/24
4836
Drug Repurposing Hub
DrugBank
DB00999
DrugBank Approved Drugs
DB00999
DrugCentral
1385
DrugCentral Approved Drugs
1385
DrugMAP
DMUSZHD
DrugMAP Approved Drugs
DMUSZHD
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101868
Guide to Pharmacology
4836
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL435
Mcule NIBR MoA Box Subset
MCULE-6585933943
MedChem Express Bioactive Compound Library
HY-B0252
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
0J48LPH2TH
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T1449
The Spectrum Collection
Withdrawn 2.0
w193
External IDs
50
Properties
(calculated by RDKit )
Molecular Weight
296.96
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
-0.35
TPSA
118.36
Fraction CSP3
0.14
Chiral centers
0.0
Largest ring
6.0
QED
0.65
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Carbonic anhydrase
Pathway
Membrane Transporter/Ion Channel
Metabolism
Stem Cell/Wnt
TGF-beta/Smad
Target
Carbonic Anhydrase
Potassium Channel
CA1, CA12, CA2, CA4, CA9, KCNMA1, SLC12A3
Member status
member
MOA
SLC12A3 gene inhibitor
thiazide diuretic
Indication
hypertension, congestive heart failure
ATC
C03AA03
Toxicity type
cardiovascular
Therapeutic Indication
Antihypertensive
Therapeutic Class
Cardiovascular
Diuretics
Source data