General
Preferred name
ROTENONE
Synonyms
Barbasco ()
Dactinol ()
Paraderil ()
Rotenon ()
Rotocide ()
P&D ID
PD002240
CAS
83-79-4
12679-58-2
Tags
nuisance
natural product
probe
drug
available
Drug Status
approved
vet_approved
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibitor of mitochondrial electron transport
(LOPAC library)
DESCRIPTION
Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
(Tocris Bioactive Compound Library)
DESCRIPTION
Rotenone is a botanical insecticide that occurs naturally in seeds and stems of several plants. Rotenone is a mitochondrial electron transport inhibitor, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC50 values of 28.8 and 5.1 nM, respectively.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
7
Organisms
4
Compound Sets
17
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
DrugBank
DrugBank Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Probe Miner (suitable probes)
Reference compounds for characterizing cellular injury in high-content cellular morphology assays
TargetMol Bioactive Compound Library
The Spectrum Collection
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
34
Molecular Weight
394.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
5
Aromatic Ring Count
2
cLogP
3.7
TPSA
63.22
Fraction CSP3
0.35
Chiral centers
3.0
Largest ring
6.0
QED
0.74
Structural alerts
1
Mitochondrial poison
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Mitochondria
Pathway
Apoptosis
Metabolism
Autophagy
Metabolic Enzyme/Protease
Target
NAPDH
p53
Mitochondrial Metabolism
Primary Target
Oxidative Phosphorylation
MOA
Inhibitor
Electron transport chain inhibitor
Apoptosis Inducers
NADH-Ubiquinone Oxidoreductase (Complex I) Inhibitors
Non-Steroidal Antiinflammatory Drugs
Electron Transport Chain Inhibitors
"Electron transport chain inhibitor
Electron Transport Chain Inhibitors"
Member status
member
Source data
