General
Preferred name
GRISEOFULVIN
Synonyms
Fulvicin ()
Amudane ()
Grisactin ()
Griseofulvin126-07-8 ()
Fulsovin ()
Fulcin 500 ()
Griseofulvin permeability diameter ()
Griseofulvin, microcrystalline ()
Grisactin v ()
Griseofulvin,Ultramicrosize ()
Grisactin Ultra ()
Fulvicin P/G 330 ()
Fulvicin P/G ()
Ultragris-330 ()
Griseofulvin, ultramicrocrystalline ()
NSC-755822 ()
Grifulvin V ()
Grivate ()
Griseofulvin, microsize ()
Griseofulvina ()
NSC-34533 ()
Griseofulvin, Ultramicrosize ()
Fulvicin-U/F ()
Fulcin 125 ()
Griseofulvin microsize ()
Fulvicin P/G 165 ()
Griseofulvine ()
Griseofulvinum ()
Grisol AF ()
Griseofulvin,microsize ()
Gris-Peg ()
Ultragris-165 ()
Fulcin ()
Griseofulvin-d3 ()
P&D ID
PD002235
CAS
126-07-8
107912-37-8
1279033-22-5
Tags
available
drug
Approved by
FDA
First approval
1962
Drug indication
Ringworm infection
Tinea pedis
Drug Status
vet_approved
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome[1][2][3][4][5][6].
DESCRIPTION
Griseofulvin is an antifungal agent used to treat a variety of superficial tinea infections and fungal infections of the fingernails and toes.
(Enamine Bioactive Compounds)
DESCRIPTION
Griseofulvin (Fulvicin) is an antifungal agent used in the treatment of TINEA infections.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
10
Organisms
7
Compound Sets
24
AdooQ Bioactive Compound Library
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine Bioactive Compounds
Enamine BioReference Compounds
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
54
Molecular Weight
352.07
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
2.81
TPSA
71.06
Fraction CSP3
0.41
Chiral centers
2.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Apoptosis
Cytoskeletal Signaling
Microbiology/virology
Anti-infection
Cell Cycle/DNA Damage
cytoskeleton
Metabolic Enzyme/Protease
Member status
member
MOA
Keratin 12 modulator
tubulin polymerization inhibitor
Indication
ringworm, tinea pedis
Target
KRT12
antibiotic
Bcl-2 Family
Caspase
Endogenous Metabolite
Fungal
Microtubule/Tubulin
WEE1
Microtubule Associated
Tubulin chain
Therapeutic Class
Antifungal Agents
Source data
